{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T05:15:27Z","timestamp":1783660527474,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32572885"],"award-info":[{"award-number":["32572885"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Phytophagous mites are widespread agricultural pests. Under persistent selection pressure from commercial acaricides,\n                      <jats:italic>Tetranychus cinnabarinus<\/jats:italic>\n                      has developed resistance to multiple acaricidal agents, reducing the control efficacy of conventional pesticides. It is therefore imperative to develop novel high\u2010efficiency candidate acaricidal compounds.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In this study, the diphenyloxazoline was selected the core scaffold. Lead compound\n                      <jats:bold>7a<\/jats:bold>\n                      was obtained\n                      <jats:italic>via<\/jats:italic>\n                      deep learning\u2010assisted molecular design. Based on this core scaffold, a series of thiosulfonate derivatives were further designed and synthesized. Bioassay results revealed that\n                      <jats:bold>7d<\/jats:bold>\n                      exhibited prominent ovicidal activity against\n                      <jats:italic>Tetranychus cinnabarinus<\/jats:italic>\n                      , with an LC\n                      <jats:sub>50<\/jats:sub>\n                      value of 0.14\u2009mg\/L, outperforming the positive control etoxazole (LC\n                      <jats:sub>50<\/jats:sub>\n                      \u2009=\u20090.55\u2009mg\/L). Moreover,\n                      <jats:bold>7d<\/jats:bold>\n                      inhibited oviposition in adult mites, displayed low toxicity toward non\u2010target organisms, and demonstrated promising antibacterial activity. Preliminary mechanistic investigations implied that chitin synthase 1 is the potential molecular target of this compound.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      Optimized thiosulfonate\n                      <jats:bold>7d<\/jats:bold>\n                      exhibits excellent ovicidal activity against\n                      <jats:italic>T. cinnabarinus<\/jats:italic>\n                      , with favorable biosafety and antibacterial activity, and is expected to be developed as a green and high\u2010efficiency acaricide. This work provides key theoretical support and technical guidance for developing new acaricides. \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.71099","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T04:49:32Z","timestamp":1783658972000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Discovery, synthesis, and acaricidal activity evaluation of deep learning\u2010assisted diphenyloxazoline thiosulfonate derivatives"],"prefix":"10.1002","author":[{"given":"Qingqaing","family":"Tian","sequence":"first","affiliation":[{"name":"Anhui Provincial Key Laboratory of Hazardous Factors and Risk Control of Agri\u2010food Quality Safety Anhui Agricultural University  Hefei 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Key Laboratory of Hazardous Factors and Risk Control of Agri\u2010food Quality Safety Anhui Agricultural University  Hefei China"},{"name":"Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinle","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Information and Artificial Intelligence Anhui Agricultural University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Information and Artificial Intelligence Anhui Agricultural University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1980-1751","authenticated-orcid":false,"given":"Yahui","family":"Li","sequence":"additional","affiliation":[{"name":"Anhui Provincial Key Laboratory of 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