{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:44:02Z","timestamp":1785908642159,"version":"3.56.0"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Plant pathogenic fungi pose a serious threat to global crop productivity. Succinate dehydrogenase inhibitors (SDHIs) exhibit superior curative activity, longer residual efficacy, and lower mammalian toxicity compared to other fungicides, making them the most studied fungicide class.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A series of N\u2010substituted phenyl pyrazole amide derivatives (\n                      <jats:bold>D1<\/jats:bold>\n                      \u2013\n                      <jats:bold>D32<\/jats:bold>\n                      ) were designed by nitrogen substitution and amide linker extension to enhance their antifungal activity and broad\u2010spectrum properties. As a result, the crystal structures of compounds\n                      <jats:bold>D6<\/jats:bold>\n                      and\n                      <jats:bold>D19<\/jats:bold>\n                      were researched, and compound\n                      <jats:bold>D19<\/jats:bold>\n                      showed strong activity against\n                      <jats:italic>Rhizoctonia cerealis<\/jats:italic>\n                      (half\u2010maximal effective concentration (EC\n                      <jats:sub>50<\/jats:sub>\n                      ) =\u20094.40\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      ), with protective and curative effects of 83.0% and 72.8% at 100\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      , respectively. Mechanistic studies revealed that compound\n                      <jats:bold>D19<\/jats:bold>\n                      could inhibit the activity of succinate dehydrogenase (SDH), disrupting the tricarboxylic acid (TCA) cycle. Molecular docking and molecular dynamics simulations confirmed the binding mode of compound\n                      <jats:bold>D19<\/jats:bold>\n                      with SDH, and toxicity assays revealed a favorable safety profile of compound\n                      <jats:bold>D19<\/jats:bold>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Novel N\u2010substituted phenyl pyrazole amide derivatives with strong antifungal activity and safety profile can be used as a lead compound for the new type of SDHI fungicide. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.71170","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T04:45:43Z","timestamp":1785905143000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design, synthesis, and antifungal activity study of\n                    <scp>N<\/scp>\n                    \u2010substituted phenyl pyrazole containing amides"],"prefix":"10.1002","author":[{"given":"Wei","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Pharmaceutical Sciences and State Key Laboratory of New Pharmaceutical Preparations and Excipients, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education Hebei University  Baoding P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renwu","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences and State Key Laboratory of New Pharmaceutical Preparations and Excipients, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education Hebei University  Baoding P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences and State Key Laboratory of New Pharmaceutical Preparations and Excipients, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education Hebei University  Baoding P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shisen","family":"Xing","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences and State Key Laboratory of New Pharmaceutical Preparations and Excipients, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education Hebei University  Baoding P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences and State Key Laboratory of New Pharmaceutical Preparations and Excipients, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education Hebei University  Baoding P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Cao","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences and State Key Laboratory of New Pharmaceutical Preparations and Excipients, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education Hebei University  Baoding P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longfei","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences and State Key Laboratory of New Pharmaceutical Preparations and Excipients, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education Hebei University  Baoding P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0472-8501","authenticated-orcid":false,"given":"Wan","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences and State Key Laboratory of New Pharmaceutical Preparations and Excipients, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education Hebei University  Baoding P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsoil.2024.105559"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12571-012-0200-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10343-017-0408-6"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.2236"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2022.836940"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/agriculture12121981"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fagro.2023.1229717"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c05854"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29010083"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.5951"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c04770"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.177665"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.62972\/1726-4685.2024.2.458"},{"key":"e_1_2_8_15_1","article-title":"A review of the recent development in the synthesis and biological evaluations of Pyrazole derivatives","volume":"10","author":"Ebenezer O","year":"2022","journal-title":"Biomedicine"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202402370"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.8410"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c07031"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2025.110912"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9SC90176K"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.8153"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-47752-x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093765"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.8943"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.6023\/cjoc201903004"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.5463"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.5773"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c12476"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.8448"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.141465"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c02757"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-64001-0"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c02158"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.9b00591"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20035"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0RA08888A"}],"container-title":["Pest Management Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ps.71170","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ps.71170","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ps.71170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T04:45:48Z","timestamp":1785905148000},"score":1,"resource":{"primary":{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/10.1002\/ps.71170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,4]]},"references-count":35,"alternative-id":["10.1002\/ps.71170"],"URL":"https:\/\/doi.org\/10.1002\/ps.71170","archive":["Portico"],"relation":{},"ISSN":["1526-498X","1526-4998"],"issn-type":[{"value":"1526-498X","type":"print"},{"value":"1526-4998","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,4]]},"assertion":[{"value":"2026-04-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ps.71170"}}