{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:43:03Z","timestamp":1786117383948,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Sclerotinia stem rot (SSR), caused by\n                      <jats:italic>Sclerotinia sclerotiorum<\/jats:italic>\n                      (Lib.) de Bary, is among the most destructive crop diseases worldwide. This study aimed to identify novel antifungal agents from\n                      <jats:italic>Pittosporum kweichowense<\/jats:italic>\n                      and elucidate their mechanisms against this pathogen.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Six eudesmane\u2010type sesquiterpenoid glycoside esters (ESGEs) were isolated from the fruit of\n                      <jats:italic>P.\u2009kweichowense<\/jats:italic>\n                      , including four new compounds pitkweifrucosides\n                      <jats:bold>A<\/jats:bold>\n                      \u2212\n                      <jats:bold>D<\/jats:bold>\n                      (\n                      <jats:bold>1<\/jats:bold>\n                      \u2013\n                      <jats:bold>4<\/jats:bold>\n                      ), and two known analogs (\n                      <jats:bold>5<\/jats:bold>\n                      \u2013\n                      <jats:bold>6<\/jats:bold>\n                      ). Their structures were established by spectroscopic analyses and comparison with authentic samples. Compound 5 (Pitsubcoside H,\n                      <jats:bold>PS\u2010H<\/jats:bold>\n                      ) showed potent antifungal activity against\n                      <jats:italic>S.\u2009sclerotiorum<\/jats:italic>\n                      with a median effective concentration of 38.61\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      . At 100\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      ,\n                      <jats:bold>PS\u2010H<\/jats:bold>\n                      inhibited mycelial growth and reduced sclerotial formation by 75.00%. It also delayed sclerotial germination at early stages and decreased oxalic acid production by 73.08%. TEM observation confirmed disruption of cellular integrity. Transcriptomic and metabolomic analyses further revealed that\n                      <jats:bold>PS\u2010H<\/jats:bold>\n                      exerts antifungal effects primarily through perturbation of amino acid metabolism and ribosomal function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      This study demonstrates that\n                      <jats:bold>PS\u2010H<\/jats:bold>\n                      exhibits significant antifungal activity against\n                      <jats:italic>S.\u2009sclerotiorum<\/jats:italic>\n                      via disruption of key metabolic pathways. These findings provide a solid basis for developing this compound as a sustainable, low\u2010toxicity alternative to conventional fungicides. \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.71183","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T13:45:28Z","timestamp":1786023928000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antifungal mechanism of eudesmane sesquiterpenoid glycosides from the fruits of\n                    <scp>\n                      <i>Pittosporum kweichowense<\/i>\n                    <\/scp>\n                    against\n                    <scp>\n                      <i>Sclerotinia sclerotiorum<\/i>\n                    <\/scp>"],"prefix":"10.1002","author":[{"given":"Gui\u2010Chun","family":"Yang","sequence":"first","affiliation":[{"name":"Shaanxi Key Laboratory of Natural 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