{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T04:25:48Z","timestamp":1786940748417,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T00:00:00Z","timestamp":1786838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T00:00:00Z","timestamp":1786838400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"abstract":"Abstract<\/jats:title>\n \n BACKGROUND<\/jats:title>\n \n Bacterial leaf blight (BLB), caused by\n Xanthomonas oryzae<\/jats:italic>\n pv.\n oryzae<\/jats:italic>\n (\n Xoo<\/jats:italic>\n ), severely threatens rice production and global food security. Current commercial bactericides such as thiadiazole copper (TC) and bismerthiazol (BT) are losing efficacy due to widespread\n Xoo<\/jats:italic>\n resistance, while research on structural modification and activity optimization of indole derivatives for\n Xoo<\/jats:italic>\n control remains scarce, highlighting an urgent need for novel, safe, and effective anti\u2010\n Xoo<\/jats:italic>\n agents and filling this research gap.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Twenty\u2010nine indole derivatives (A1\u2013A29) were synthesized from 3\u2010carboxyindole (structures confirmed by\n 1<\/jats:sup>\n H NMR,\n 13<\/jats:sup>\n C NMR, HRMS). A29 showed superior anti\u2010\n Xoo<\/jats:italic>\n activity (EC\n 50<\/jats:sub>\n \u2009=\u20091.24\u2009\u03bcg\/mL), low phytotoxicity, high selectivity, and better greenhouse efficacy (51% curative, 50% preventive) than BT and TC. Mechanistically, A29 exerts its effects through multiple pathways that include EPS and biofilm modulation, ROS\u2010mediated apoptosis induction, and regulation of key genes, as validated by RT\u2010qPCR.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n \n A29, safe, potent multi\u2010mechanistic lead, exerts multimodal anti\u2010\n Xoo<\/jats:italic>\n effects by disrupting key processes, virulence, promising as novel agrochemical for BLB. \u00a9 2026 Society of Chemical Industry.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ps.71204","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T04:07:34Z","timestamp":1786939654000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design, synthesis, and multitarget anti\u2010\n Xanthomonas oryzae<\/i>\n pv.\n oryzae<\/i>\n mechanism of indole\u20103\u2010substituted aryl urea derivatives"],"prefix":"10.1002","author":[{"given":"Mengzhi","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Green Pesticide, Center for R&D of Fine Chemicals of Guizhou University Guiyang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anbang","family":"Bai","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Guizhou Engineering Laboratory for Synthetic Drugs, Guizhou University Guiyang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2956-7639","authenticated-orcid":false,"given":"Chenchen","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Guizhou Engineering Laboratory for Synthetic Drugs, Guizhou University Guiyang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1859-0128","authenticated-orcid":false,"given":"Zhenchao","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Green Pesticide, Center for R&D of Fine Chemicals of Guizhou University Guiyang People's Republic of China"},{"name":"School of Pharmaceutical Sciences, Guizhou Engineering Laboratory for Synthetic Drugs, Guizhou University Guiyang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.eswa.2024.123643","article-title":"Identification of rice disease under complex background based on PSOC\u2010DRCNet","volume":"249","author":"Liu ZW","year":"2024","journal-title":"Expert Syst Appl"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2022.214701","article-title":"Recent progress in multifunctional conjugated polymer nanomaterial\u2010based synergistic combination phototherapy for microbial infection theranostics","volume":"470","author":"Manivasagan P","year":"2022","journal-title":"Coord Chem Rev"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4236\/jcc.2023.119004","article-title":"Plant disease severity assessment based on machine learning and deep learning: a survey","volume":"11","author":"Faye D","year":"2023","journal-title":"J Comput Commun"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2022239118","article-title":"The persistent threat of emerging plant disease pandemics to global food security","volume":"118","author":"Ristaino JB","year":"2021","journal-title":"Proc Natl Acad Sci"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2026.1744367","article-title":"Resistance gene against Xanthomonas oryzae pv. 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