{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T06:23:31Z","timestamp":1787207011526,"version":"build-2736575974"},"reference-count":65,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"abstract":"Abstract<\/jats:title>\n \n BACKGROUND<\/jats:title>\n Phytopathogenic bacteria threaten global food security by reducing crop yields, degrading quality, and causing mycotoxin contamination. Therefore, there is an urgent need to develop highly effective bactericides with novel mechanisms of action. FtsZ (filamentous temperature\u2010sensitive protein Z) a key protein that forms the Z\u2010ring at the cell center to coordinate division. Although it has been recognized as an important target for novel antibacterial agents, research on its agricultural inhibitors remains relatively scarce.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Using active fragment combination strategy, we rationally designed and synthesized a series of 2\u2010alkenylquinolin\u20101\u2010ium derivatives and rigorously evaluated their antimicrobial efficacy against three agriculturally devastating pathogens:\n Xanthomonas oryzae<\/jats:italic>\n pv.\n oryzae<\/jats:italic>\n (\n Xoo<\/jats:italic>\n ),\n Xanthomonas axonopodis<\/jats:italic>\n pv.\n citri<\/jats:italic>\n (\n Xac<\/jats:italic>\n ), and\n Pseudomonas syringae<\/jats:italic>\n pv.\n actinidiae<\/jats:italic>\n (\n Psa<\/jats:italic>\n ). Among them, compound\n A11<\/jats:bold>\n exhibited exceptional antibacterial activity against all three pathogens with half\u2010maximal effective concentration (EC\n 50<\/jats:sub>\n ) values of 0.024, 0.074, and 3.428\u2009\u03bcg\/mL respectively. Formulation with adjuvant fatty alcohol polyglycolether (MOA\u20103) changed its physicochemical properties and improved foliar adhesion on the surface of leaves, increasing\n in vivo<\/jats:italic>\n disease control efficacy from 44.82% to 55.41%. Mechanistic profiling revealed compound\n A11<\/jats:bold>\n binds to the interdomain cleft of\n Xoo<\/jats:italic>\n FtsZ, inhibits\n Xoo<\/jats:italic>\n FtsZ polymerization, and induced bacterial filamentation. Furthermore, compound\n A11<\/jats:bold>\n demonstrated favorable biosafety parameters with low phytotoxicity and negligible earthworm toxicity.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n \n This study validates FtsZ, an evolutionarily conserved bacterial division protein, as a strategic target for antimicrobial development, and identifies compound\n A11<\/jats:bold>\n as a potent, environmentally friendly FtsZ inhibitor. Beyond providing a promising\n Xoo<\/jats:italic>\n FtsZ lead compound, this work establishes a theoretical basis for bactericide design. \u00a9 2026 Society of Chemical Industry.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ps.71205","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T05:25:55Z","timestamp":1787203555000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unraveling 2\u2010alkenylquinolin\u20101\u2010ium derivatives as bacterial division inhibitors: bactericidal effect against food and fruits bacteria for ensuring food safety"],"prefix":"10.1002","author":[{"given":"Wan","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University Guiyang 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of Guizhou University Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Sha","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3589-9074","authenticated-orcid":false,"given":"Xiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Green Pesticides, Key Laboratory of 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