{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:05:27Z","timestamp":1789182327604,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Cumin essential oil from\n                      <jats:italic>Cuminum cyminum<\/jats:italic>\n                      is a promising alternative to synthetic fungicides because of its broad\u2010spectrum antifungal activity and environmental compatibility. However, its major active constituent and antifungal mechanism remain unclear. Using\n                      <jats:italic>Magnaporthe oryzae<\/jats:italic>\n                      Guy11, the causal agent of rice blast as model, this study identified the major antifungal constituent of cumin essential oil and investigated its mode of action.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Twelve major constituents were identified by gas chromatography\u2013mass spectrometry, with cumin aldehyde as the predominant component (42.51%). Comparative antifungal assays showed that cumin aldehyde is the principal active constituent, which significantly inhibits mycelial growth, conidial germination, appressorium formation, and pathogenicity of\n                      <jats:italic>M. oryzae<\/jats:italic>\n                      . Microscopic analyses showed that cumin aldehyde disrupts membrane integrity, alters cell wall organization, and induces excessive reactive oxygen species accumulation in\n                      <jats:italic>M. oryzae<\/jats:italic>\n                      . Transcriptome analysis revealed marked changes in genes associated with cell wall biosynthesis, oxidative stress response, DNA replication, and protein glycosylation. Detached rice leaf assays further demonstrated protective and curative activities of 62.14% and 41.46%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      Cumin aldehyde is the major antifungal constituent of cumin essential oil and suppresses\n                      <jats:italic>M. oryzae<\/jats:italic>\n                      through coordinated disruption of membrane integrity, oxidative homeostasis, and cellular metabolism. These findings provide new insights into the antifungal mechanism of cumin essential oil and support the potential application of cumin aldehyde as a botanical fungicide for rice blast management. \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.71221","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:14:26Z","timestamp":1789179266000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Insights into antifungal mechanism of cumin aldehyde against\n                    <scp>\n                      <i>Magnaporthe oryzae<\/i>\n                    <\/scp>"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6982-7027","authenticated-orcid":false,"given":"Huizhen","family":"Xue","sequence":"first","affiliation":[{"name":"College of Sciences, Nanjing Agricultural University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songcheng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, College of Life Sciences, Nanjing Agricultural University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, College of Life Sciences, Nanjing Agricultural University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurun","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Center for Standardization Technology Evaluation, State Administration for Market Regulation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengjie","family":"Shu","sequence":"additional","affiliation":[{"name":"Nanjing Institute for Comprehensive Utilization of Wild Plants  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunwu","family":"Wang","sequence":"additional","affiliation":[{"name":"Xinjiang Agricultural Technology Promotion Station  Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beiwei","family":"Hou","sequence":"additional","affiliation":[{"name":"Nanjing Institute for Comprehensive Utilization of Wild Plants  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihui","family":"Nie","sequence":"additional","affiliation":[{"name":"Xinjiang Academy of Agricultural Sciences  Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunlin","family":"Gu","sequence":"additional","affiliation":[{"name":"Yuepuhu Cumin Science and Technology Institute Co., Ltd.  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