{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T05:23:55Z","timestamp":1787117035096,"version":"build-2736575974"},"reference-count":66,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003704","name":"Korea Research Institute of Chemical Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003627","name":"Rural Development Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003627","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"abstract":"Abstract<\/jats:title>\n \n BACKGROUND<\/jats:title>\n \n In the search for biological resources with antibacterial activity against\n Erwinia amylovora<\/jats:italic>\n , the culture filtrate of\n Lentinula edodes<\/jats:italic>\n HK761 exhibited strong\n in vitro<\/jats:italic>\n activity. This study aimed to: (i) identify the antibacterial compound produced by\n L<\/jats:italic>\n .\n edodes<\/jats:italic>\n HK761; and (ii) evaluate its antibacterial activity and mode of action.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Using bioassay\u2010guided fractionation of antibacterial activity, an active compound was isolated from the culture filtrate of\n L<\/jats:italic>\n .\n edodes<\/jats:italic>\n HK761 and identified by spectroscopic analyses as edodine. When edodine was applied to Chinese pearleaf crabapple seedlings, necrosis was limited to the leaf rudiment and leaf blades, with a disease control value of 89% at a concentration of 100\u2009\u03bcg\u2009mL\n \u22121<\/jats:sup>\n . In the transcriptomic profiles, edodine altered gene expression patterns, particularly in pathways related to metabolism and cellular processes. Edodine reduced swarming motility and induced cell elongation in\n E<\/jats:italic>\n .\n amylovora<\/jats:italic>\n , along with transcriptomic changes in genes related to motility and protein folding. Edodine reduced intracellular ATP levels by 40% and 53% at concentrations of 2 and 5\u2009\u03bcg\u2009mL\n \u22121<\/jats:sup>\n , respectively. Furthermore, edodine exhibited synergistic antibacterial effects when combined with conventional antibiotics.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n \n Given the strong disease control efficacy of\n L<\/jats:italic>\n .\n edodes<\/jats:italic>\n HK761 and its active compound edodine, our findings provide a solid foundation for developing new biological control agents for fire blight disease. \u00a9 2026 The Author(s).\n Pest Management Science<\/jats:italic>\n published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ps.71223","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T04:25:06Z","timestamp":1787113506000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Discovery of edodine, a natural compound from\n \n Lentinula edodes<\/i>\n <\/scp>\n with antibacterial activity for the biological control of fire blight pathogen\n \n Erwinia amylovora<\/i>\n <\/scp>"],"prefix":"10.1002","author":[{"given":"Yeong Seok","family":"Kim","sequence":"first","affiliation":[{"name":"Center for Eco\u2010friendly New Materials Korea Research Institute of Chemical Technology Daejeon Republic of Korea"},{"name":"Department of Medicinal Chemistry and Pharmacology University of Science and Technology Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Woo","family":"Han","sequence":"additional","affiliation":[{"name":"Center for Eco\u2010friendly New Materials Korea Research Institute of Chemical Technology Daejeon Republic of Korea"},{"name":"Department of Medicinal Chemistry and Pharmacology University of Science and Technology Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bomin","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Eco\u2010friendly New Materials Korea Research Institute of Chemical Technology Daejeon Republic of Korea"},{"name":"Department of Medicinal Chemistry and Pharmacology University of Science and Technology Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunggeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Biomimetic Research, Division of Advanced Predictive Research Korea Institute of Toxicology Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daeui","family":"Park","sequence":"additional","affiliation":[{"name":"Center for Biomimetic Research, Division of Advanced Predictive Research Korea Institute of Toxicology Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaehyuk","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Life Sciences Incheon National University Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyung Ja","family":"Choi","sequence":"additional","affiliation":[{"name":"Center for Eco\u2010friendly New Materials Korea Research Institute of Chemical Technology Daejeon Republic of Korea"},{"name":"Department of Medicinal Chemistry and Pharmacology University of Science and Technology Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6727-4469","authenticated-orcid":false,"given":"Hun","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Eco\u2010friendly New Materials Korea Research Institute of Chemical Technology Daejeon Republic of Korea"},{"name":"Department of Medicinal Chemistry and Pharmacology University of Science and Technology Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1007\/s13197-018-3195-x","article-title":"Nutritional characterization of apple as a function of genotype","volume":"55","author":"Kumar P","year":"2018","journal-title":"J Food Sci Technol"},{"key":"e_1_2_9_3_1","article-title":"Malus domestica: a review on nutritional features, chemical composition, traditional and medicinal value","volume":"9","author":"Patocka J","year":"2020","journal-title":"Plants (Basel, Switz)"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.scienta.2022.111075","article-title":"Apple pathogens: organic essential oils as an alternative solution","volume":"300","author":"Di Francesco A","year":"2022","journal-title":"Sci 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