{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T01:45:57Z","timestamp":1788918357048,"version":"build-2803163510"},"reference-count":69,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFD1401100"],"award-info":[{"award-number":["2021YFD1401100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Despite their crucial roles in insect olfaction and insecticide resistance, the functional diversity of chemosensory proteins (CSPs) remains largely underexplored due to challenges in their characterization. Leveraging the protein interactome for the functional characterization of CSPs may represent a feasible approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      An interactome approach was utilized to elucidate the function of NlCSP1 in\n                      <jats:italic>Nilaparvata lugens<\/jats:italic>\n                      . We identified a GRP94\/LMAN1\u2010MCFD2 axis that governs the folding and secretion of NlCSP1. NlGRP94 and NlGRP78 act as chaperones, and NlLMAN1\u2013NlMCFD2 complex controls its endoplasmic reticulum (ER) to Golgi apparatus (GA) trafficking. Furthermore, the secretion of CSPs and odorant\u2010binding proteins (OBPs) in insects may be broadly regulated by the GRP94\/LMAN1\u2010MCFD2 axis. In addition to secretion, NlCSP1 directly interacts with the carboxylesterase NlCarE6\u20101, forming a complex that may enhance ligand\u2010binding affinity and associates with lipid\u2010like molecules.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      These results reveal a previously unrecognized regulatory axis, the GRP94\/LMAN1\u2010MCFD2 pathway, which maintains the homeostasis of CSPs\/OBPs. Moreover, the CSP\u2013carboxylesterase complex may represent a novel mechanism contributing to odorant degradation and insecticide resistance, pending\n                      <jats:italic>in vivo<\/jats:italic>\n                      functional validation. These findings highlight the potential for targeting secretion via this axis or disrupting the CSP\u2010 carboxylesterase complex as a strategy for species\u2010specific pest management. \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.71231","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T04:23:37Z","timestamp":1787113417000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The\n                    <scp>GRP94<\/scp>\n                    \/\n                    <scp>LMAN1<\/scp>\n                    \u2010\n                    <scp>MCFD2<\/scp>\n                    axis controls secretion of chemosensory proteins and enables a carboxylesterase complex in\n                    <i>Nilaparvata lugens<\/i>"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6455-0509","authenticated-orcid":false,"given":"Ao","family":"Liu","sequence":"first","affiliation":[{"name":"Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory, College of Plant Science and Technology, Huazhong Agricultural University  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Zhen","family":"Li","sequence":"additional","affiliation":[{"name":"Ecology and Nature Conservation Institute, Chinese Academy of forestry  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui\u2010Nan","family":"Yang","sequence":"additional","affiliation":[{"name":"Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory, College of Plant Science and Technology, Huazhong Agricultural University  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei\u2010Jiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory, College of Plant Science and Technology, Huazhong Agricultural University  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazem","family":"Abdelnabby","sequence":"additional","affiliation":[{"name":"Department of Plant Protection, Faculty of Agriculture Benha University  Banha Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1768-0722","authenticated-orcid":false,"given":"Man\u2010Qun","family":"Wang","sequence":"additional","affiliation":[{"name":"Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory, College of Plant Science and Technology, Huazhong Agricultural University  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1","volume-title":"The Chemistry of Pheromones and Other Semiochemicals II","author":"Leal WS","year":"2005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1093\/gbe\/evr033","article-title":"Comparative genomics of the odorant\u2010binding and chemosensory protein gene families across the arthropoda: origin and evolutionary history of the chemosensory system","volume":"3","author":"Vieira FG","year":"2011","journal-title":"Genome Biol Evol"},{"key":"e_1_2_8_4_1","first-page":"1","article-title":"Insights into the evolution of the CSP gene family through the integration of evolutionary analysis and comparative protein modeling","volume":"8","author":"Kannan N","year":"2013","journal-title":"PLoS 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