{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:18:07Z","timestamp":1787919487190,"version":"build-2784847793"},"reference-count":65,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      The South American tomato pinworm,\n                      <jats:italic>Phthorimaea absoluta<\/jats:italic>\n                      , has developed resistance to diamide insecticides mainly through target\u2010site mutations in the ryanodine receptor (RyR), including I4746M, G4903E, and G4903V. Recently, a novel mutation, I4746K, has been identified in field populations of\n                      <jats:italic>P<\/jats:italic>\n                      .\n                      <jats:italic>absoluta<\/jats:italic>\n                      , but its contribution to resistance remains unclear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>In this study, a field population (TR\u2010Kr\u015f\u201021) harboring the I4746K mutation exhibited 116.65\u2010fold resistance to chlorantraniliprole (CHL). After six rounds of laboratory selection with CHL, resistance increased to 1109.94\u2010fold (CHL\u2010Sel), with a realized heritability of 0.58. Resistance remained stable for 1\u2009year without insecticide exposure, and genetic analyses indicated that it is autosomal, incompletely dominant, and polygenic. Cross\u2010resistance was observed among diamide insecticides, but not to abamectin or broflanilide. Synergist bioassays with piperonyl butoxide and diethyl maleate showed that inhibition of detoxification enzymes did not fully restore susceptibility. CHL selection resulted in a positive correlation between I4746K allele frequency and resistance, and genetic linkage analysis confirmed a significant association between the mutation and the resistant phenotype. Modeling and molecular dynamics simulations revealed that the I4746K substitution reshapes ligand\u2013receptor interactions without markedly reducing overall binding affinity. Finally, a quantitative sequencing protocol and a tetra\u2010primer amplification\u2010refractory mutation system polymerase chain reaction assay were developed for rapid detection of the I4746K mutation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      This study emphasizes the significance of the I4746K mutation in diamide resistance and offers valuable insights into how this mutation variably influences the binding of diamide insecticides, thereby informing strategies for resistance management in\n                      <jats:italic>P<\/jats:italic>\n                      .\n                      <jats:italic>absoluta<\/jats:italic>\n                      . \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.71234","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T11:58:31Z","timestamp":1787918311000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The\n                    <scp>I4746K<\/scp>\n                    mutation in the ryanodine receptor is associated with high\u2010level resistance to diamide insecticides in\n                    <i>Phthorimaea absoluta<\/i>"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4884-4002","authenticated-orcid":false,"given":"Abdullah Emre","family":"At\u0131\u015f","sequence":"first","affiliation":[{"name":"Directorate of Plant Protection Central Research Institute  Ankara T\u00fcrkiye"},{"name":"Biotechnology Institute Ankara University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00fcbra Kahveci","family":"G\u00fcnd\u00fcz","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics Bogazici University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alize","family":"Y\u0131lmazlar","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics Bogazici University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0411-4198","authenticated-orcid":false,"given":"Emre","family":"\u0130nak","sequence":"additional","affiliation":[{"name":"Department of Plant Protection, Faculty of Agriculture Ankara University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Necla Birg\u00fcl","family":"Iyison","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics Bogazici University  Istanbul T\u00fcrkiye"},{"name":"Center for Targeted Therapy Technologies Bogazici University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Erg\u00fcl","sequence":"additional","affiliation":[{"name":"Department of Plant Protection, Faculty of Agriculture Ankara University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1007\/s10340-018-1062-1","article-title":"Tuta absoluta continues to disperse in Asia: damage, ongoing management and future challenges","volume":"92","author":"Han P","year":"2019","journal-title":"J Pest Sci"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s12600-010-0095-7","article-title":"First record of Tuta absoluta in Turkey","volume":"38","author":"K\u0131l\u0131\u00e7 T","year":"2010","journal-title":"Phytoparasitica"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10340-021-01442-8","article-title":"Integrated pest management of Tuta absoluta: practical implementations across different world regions","volume":"95","author":"Desneux N","year":"2022","journal-title":"J Pest Sci"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1146\/annurev-ento-031616-034933","article-title":"Ecology, worldwide spread, and Management of the Invasive South American Tomato Pinworm, Tuta absoluta\u2009: past, present, and future","volume":"63","author":"Biondi A","year":"2018","journal-title":"Annu Rev Entomol"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/978-3-319-31800-4_7","volume-title":"Advances in Insect Control and Resistance Management","author":"P\u00e9rez\u2010Hedo M","year":"2016"},{"key":"e_1_2_9_7_1","unstructured":"APRD Arthropod Pesticide Resistance Database(2026). 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