{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T08:12:29Z","timestamp":1788423149719,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      The persistent proliferation of bacterial phytopathogens presents a significant threat to global food security and agricultural sustainability. Among these pathogens, species belonging to the\n                      <jats:italic>genus Xanthomonas<\/jats:italic>\n                      are particularly destructive.\n                      <jats:italic>Xanthomonas oryzae<\/jats:italic>\n                      pv\n                      <jats:italic>. oryzae<\/jats:italic>\n                      (\n                      <jats:italic>Xoo<\/jats:italic>\n                      ), the causal agent of bacterial leaf blight in rice, is recognized as one of the most devastating phytopathogens. This strongly indicates that there is an urgent need to create green small\u2010molecule pesticides specifically targeting\n                      <jats:italic>Xoo<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Herein, we designed and synthesized 20 oxime ether derivatives containing piperazine fragments and systematically evaluated their antibacterial activity. Bioassay results revealed that compound L1 exhibited notable antibacterial efficacy, with a half\u2010maximal effective concentration (EC\n                      <jats:sub>50<\/jats:sub>\n                      ) of 7.32\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      , significantly outperforming control agents such as thiodiazole\u2010copper (96.90\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) and bismerthiazol (47.20\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      ). The underlying mechanism of action was investigated using an integrated approach involving molecular docking, morphological observation, three\u2010dimensional quantitative structure\u2013activity relationship modeling, and transcriptome profiling. In addition, the phytotoxicity study results indicate that compound L1 exhibits low toxicity towards plants. The findings of this research provide theoretical insights and experimental guidance for designing novel, potent, and environment\u2010friendly small\u2010molecule antibacterial agents.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      Compound L1 represents a promising class of antibacterial agents with potent activity against\n                      <jats:italic>Xoo<\/jats:italic>\n                      . It possesses the dual advantages of high bactericidal efficacy and ecological friendliness, demonstrating great potential to replace traditional agricultural chemicals and promote green prevention and control of plant diseases. \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.71245","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T02:30:45Z","timestamp":1787970645000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis, antibacterial evaluation, and mechanism study of piperazine\u2010bearing oxime ether derivatives"],"prefix":"10.1002","author":[{"given":"Yuguo","family":"Zheng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education Center for R&amp;D of Fine Chemicals of Guizhou 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