{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:20:21Z","timestamp":1787808021935,"version":"build-2784847793"},"reference-count":65,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Paeonol is the main active ingredient in root bark of\n                      <jats:italic>Paeonia suffruticosa<\/jats:italic>\n                      , with broad\u2010spectrum bioactivity. Additionally, isoxazoline\/isoxazole is becoming the core skeleton for creating efficient and green pesticides today owing to its unique structural advantages and bioactivity potential.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In order to discover biorational natural product\u2010based pesticides, 26 novel paeonol ether derivatives (\n                      <jats:bold>3a\u2013q<\/jats:bold>\n                      and\n                      <jats:bold>5a<\/jats:bold>\n                      ,\n                      <jats:bold>c<\/jats:bold>\n                      ,\n                      <jats:bold>d<\/jats:bold>\n                      ,\n                      <jats:bold>f\u2013j<\/jats:bold>\n                      ,\n                      <jats:bold>m<\/jats:bold>\n                      ) were synthesized by ingeniously introducing an isoxazoline\/isoxazole ring, and their structures were well\u2010characterized by\n                      <jats:sup>proton<\/jats:sup>\n                      and carbon nuclear magnetic resonance (NMR), and high\u2010resolution mass spectrometry (HRMS). The stereochemical configurations of five target compounds\n                      <jats:bold>3a<\/jats:bold>\n                      ,\n                      <jats:bold>3g<\/jats:bold>\n                      ,\n                      <jats:bold>3j<\/jats:bold>\n                      ,\n                      <jats:bold>5a<\/jats:bold>\n                      and\n                      <jats:bold>5h<\/jats:bold>\n                      were unambiguously subjected to single\u2010crystal X\u2010ray diffraction (XRD) analysis. Furthermore, we screened the bioactivities of these compounds as anti\u2010oomycete, antifungal and nematicidal agents. Amongst evaluated derivatives, (1) compounds\n                      <jats:bold>2<\/jats:bold>\n                      and\n                      <jats:bold>4<\/jats:bold>\n                      displayed promising anti\u2010oomycete against the plant pathogen\n                      <jats:italic>Phytophthora capsici<\/jats:italic>\n                      , with median effective concentration (EC\n                      <jats:sub>50<\/jats:sub>\n                      )values of 28.51 and 42.52\u2009mg\u2009L\n                      <jats:sup>\u20131<\/jats:sup>\n                      , respectively. (2) Compounds\n                      <jats:bold>2<\/jats:bold>\n                      and\n                      <jats:bold>4<\/jats:bold>\n                      also exhibited excellent antifungal activity against the plant pathogen\n                      <jats:italic>Fusarium graminearum<\/jats:italic>\n                      , with EC\n                      <jats:sub>50<\/jats:sub>\n                      values of 29.11 and 31.23\u2009mg\u2009L\n                      <jats:sup>\u20131<\/jats:sup>\n                      , respectively. (3) Nine compounds (\n                      <jats:bold>3f\u2013h<\/jats:bold>\n                      ,\n                      <jats:bold>j<\/jats:bold>\n                      ,\n                      <jats:bold>o\u2013q<\/jats:bold>\n                      and\n                      <jats:bold>5f<\/jats:bold>\n                      ,\n                      <jats:bold>g<\/jats:bold>\n                      ) showed significant nematicidal activity against\n                      <jats:italic>Heterodera glycines<\/jats:italic>\n                      , with LC\n                      <jats:sub>50<\/jats:sub>\n                      values all &lt;30.00\u2009mg\u2009L\n                      <jats:sup>\u20131<\/jats:sup>\n                      . Especially for compound\n                      <jats:bold>3g<\/jats:bold>\n                      , its LC\n                      <jats:sub>50<\/jats:sub>\n                      value is the smallest, at 21.78\u2009mg\u2009L\n                      <jats:sup>\u20131<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>The research results indicate that, on the one hand, introducing an allyl or propargyl group at the hydroxyl position of paeonol can effectively enhance its anti\u2010oomycete and antifungal activities. On the other hand, further introduction of an isoxazoline\/isoxazole ring into the structural skeleton of paeonol can significantly enhance its nematicidal activity. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.71249","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T04:59:48Z","timestamp":1787806788000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design, synthesis, and anti\u2010oomycete, antifungal and nematicidal activities of novel paeonol ether derivatives containing isoxazoline\/isoxazole moiety"],"prefix":"10.1002","author":[{"given":"Xiaxia","family":"Ban","sequence":"first","affiliation":[{"name":"Department of Plant Protection, Laboratory of Pesticidal Design &amp; Synthesis, College of Horticultrue and Plant Protection Henan University of Science and Technology  Luoyang 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