{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:18:09Z","timestamp":1788499089886,"version":"build-2803163510"},"reference-count":73,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Plant fungal diseases cause significant agricultural losses, and\n                      <jats:italic>Streptomyces<\/jats:italic>\n                      \u2010derived antifungal compounds offer a promising biocontrol strategy. This study aimed to isolate and characterize bioactive metabolites from\n                      <jats:italic>Streptomyces syringium<\/jats:italic>\n                      LZ036 and evaluate their activity and mechanism of action against\n                      <jats:italic>Botrytis cinerea<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A strain LZ036 with broad\u2010spectrum antifungal activity was identified as\n                      <jats:italic>Streptomyces syringium<\/jats:italic>\n                      . The 3\u2010(oxazole\u20105\u2010yl) indole compound\n                      <jats:bold>NL3<\/jats:bold>\n                      isolated from this strain exhibited potent broad\u2010spectrum antifungal activity, especially against\n                      <jats:italic>Botrytis cinerea<\/jats:italic>\n                      . Compound\n                      <jats:bold>NL3<\/jats:bold>\n                      inhibited fungal growth and development by inducing severe oxidative damage and membrane disruption. And it could trigger jasmonic acid (JA)\u2010dependent induced systemic resistance (ISR) in plants. Transcriptomic analysis of compound\n                      <jats:bold>NL3<\/jats:bold>\n                      \u2010treated\n                      <jats:italic>Botrytis cinerea<\/jats:italic>\n                      revealed genome\u2010wide transcriptional alterations, including disruption of energy metabolism and mitochondrial function. Key genes related to mitogen\u2010activated protein kinase (MAPK) signaling pathway down\u2010regulated significantly, among which the catalytic S_TKc domain of Bcste7 exhibited a predicted interaction with compound\n                      <jats:bold>NL3<\/jats:bold>\n                      through hydrophobic interactions and hydrogen bonding.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic>Streptomyces syringium<\/jats:italic>\n                      \u2010derived compound\n                      <jats:bold>NL3<\/jats:bold>\n                      shows high potential as a green fungicide, acting through multiple mechanisms. These findings advance the development of\n                      <jats:italic>Streptomyces<\/jats:italic>\n                      \u2010based antifungal agents. \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.71251","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:41:16Z","timestamp":1788496876000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unlocking antifungal mechanisms of natural 3\u2010(oxazole\u20105\u2010yl) indole compound derived from\n                    <scp>\n                      <i>Streptomyces syringium<\/i>\n                    <\/scp>\n                    against plant gray mold caused by\n                    <scp>\n                      <i>Botrytis cinerea<\/i>\n                    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