{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:06:02Z","timestamp":1789182362474,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Fungus\n                      <jats:italic>Podosphaera xanthii<\/jats:italic>\n                      (syn.\n                      <jats:italic>Sphaerotheca fuliginea<\/jats:italic>\n                      ) can cause cucurbit powdery mildew, posing a serious threat to cucurbit production. Chemical control is widely preferred for managing powdery mildew on cucurbits. A series of novel tryptamine derivatives were designed and synthesized, and their curative activity against\n                      <jats:italic>Podosphaera xanthii<\/jats:italic>\n                      was systematically evaluated using a whole\u2010plant bioassay.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      <jats:italic>In vivo<\/jats:italic>\n                      activity assays of the tryptamine derivatives against\n                      <jats:italic>P.\u2009xanthii<\/jats:italic>\n                      revealed that\n                      <jats:bold>13h<\/jats:bold>\n                      and\n                      <jats:bold>5o<\/jats:bold>\n                      exhibited excellent curative effects, with median effective concentration (EC\n                      <jats:sub>50<\/jats:sub>\n                      ) values of 18.07 and 22.08\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      , respectively, comparable to that of the positive control difenoconazole (EC\n                      <jats:sub>50<\/jats:sub>\n                      \u2009=\u200914.77\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      ). Scanning electron microscopy (SEM) and Coomassie Brilliant Blue R\u2010250 staining demonstrated that compound\n                      <jats:bold>13h<\/jats:bold>\n                      induced pronounced hyphal breakage, collapse and disintegration, along with pronounced curling. Additionally, transmission electron microscopy (TEM) observations confirmed that\n                      <jats:bold>13h<\/jats:bold>\n                      compromised cellular integrity, leading to irreversible organelle damage and tissue disintegration, ultimately suppressing hyphal proliferation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      Structure\u2013activity relationships (SARs) were established for a new type of tryptamine derivatives incorporating aromatic aldehyde and amide moieties, providing guidance for designing tryptamine\u2010based antifungal agents. Given the potent curative activity of compound\n                      <jats:bold>13h<\/jats:bold>\n                      , it holds great promise as a novel antifungal agent. \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.71276","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:28:10Z","timestamp":1789180090000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel tryptamine derivatives incorporating aromatic aldehyde and amide moieties: design, synthesis, and antifungal activity"],"prefix":"10.1002","author":[{"given":"Ke\u2010Yin","family":"Yu","sequence":"first","affiliation":[{"name":"College of Chemistry &amp; Pharmacy Northwest A&amp;F University  Yangling China"},{"name":"Key Laboratory of Botanical Pesticide R&amp;D in Shaanxi Province College of Plant Protection, Northwest A&amp;F 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