{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:06:26Z","timestamp":1789103186468,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1700700"],"award-info":[{"award-number":["2023YFD1700700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD1600100"],"award-info":[{"award-number":["2022YFD1600100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21977083"],"award-info":[{"award-number":["21977083"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22571256"],"award-info":[{"award-number":["22571256"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22371231"],"award-info":[{"award-number":["22371231"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"abstract":"Abstract<\/jats:title>\n \n BACKGROUND<\/jats:title>\n \n Agricultural pests significantly reduce crop yields and threaten global food security. Chemical pesticides remain the primary means of pest control. In this study, celangulin V, a plant\u2010derived insecticide, was used as a lead compound. Guided by three\u2010dimensional quantitative structure\u2013activity relationship (3D\u2010QSAR) modeling and based on the tricyclic scaffold of dihydroagarofuran, a series of dihydroagarofuran oxime ether derivatives were designed and synthesized, and their insecticidal activity against\n Mythimna separata<\/jats:italic>\n was evaluated using a leaf\u2010dip bioassay.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Compounds\n 3g<\/jats:bold>\n and\n 4g<\/jats:bold>\n showed excellent activity, with median lethal concentration (LC\n 50<\/jats:sub>\n ) values of 18 and 11\u2009mg\u00b7L\n \u22121<\/jats:sup>\n , respectively, compared with 9\u2009mg\u2009L\n \u22121<\/jats:sup>\n for the reference insecticide fipronil under the same laboratory conditions, and up to 960\u2010fold more potent than celangulin V. Symptomatological analysis revealed poisoning symptoms similar to those induced by celangulin V. Molecular docking suggested that compounds\n 3g<\/jats:bold>\n and\n 4g<\/jats:bold>\n may occupy a putative binding region of the modeled V\u2010ATPase H subunit and form potential halogen\u2010bonding interactions with nearby amino acid residues.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n \n The structure\u2013activity relationships of the dihydroagarofuran oxime ether derivatives were established and further elucidated using comparative molecular field analysis (CoMFA), providing valuable guidance for the rational design of novel insecticides. Among the compounds, compound\n 4g<\/jats:bold>\n exhibited significant potential and can be regarded as a promising insecticidal candidate. \u00a9 2026 Society of Chemical Industry.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ps.71302","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T04:20:10Z","timestamp":1789100410000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design, synthesis, and insecticidal activity of dihydroagarofuran\u2010based oxime ether analogs against\n \n Mythimna separata<\/i>\n <\/scp>\n as potential insecticides"],"prefix":"10.1002","author":[{"given":"Ziyu","family":"Wang","sequence":"first","affiliation":[{"name":"College of Chemistry and Pharmacy Northwest A&F University Shaanxi China"},{"name":"Key Laboratory of Botanical Pesticide R&D in Shaanxi Province College of Plant Protection, Northwest A&F University Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Pharmacy Northwest A&F University Shaanxi China"},{"name":"Key Laboratory of Botanical Pesticide R&D in Shaanxi Province College of Plant Protection, Northwest A&F University Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Tang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Pharmacy Northwest A&F University Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Long","sequence":"additional","affiliation":[{"name":"College of Chemistry and Pharmacy Northwest A&F University Shaanxi China"},{"name":"Key Laboratory of Botanical Pesticide R&D in Shaanxi Province College of Plant Protection, Northwest A&F University Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxiang","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Pharmacy Northwest A&F University Shaanxi China"},{"name":"Key Laboratory of Botanical Pesticide R&D in Shaanxi Province College of Plant Protection, Northwest A&F University Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziguang","family":"Shang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Pharmacy Northwest A&F University Shaanxi China"},{"name":"Key Laboratory of Botanical Pesticide R&D in Shaanxi Province College of Plant Protection, Northwest A&F University Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Qian","sequence":"additional","affiliation":[{"name":"College of Chemistry and Pharmacy Northwest A&F University Shaanxi China"},{"name":"Key Laboratory of Botanical Pesticide R&D in Shaanxi Province College of Plant Protection, Northwest A&F University Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Botanical Pesticide R&D in Shaanxi Province College of Plant Protection, Northwest A&F University Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqing","family":"Xie","sequence":"additional","affiliation":[{"name":"College of Chemistry and Pharmacy Northwest A&F University Shaanxi China"},{"name":"Key Laboratory of Botanical Pesticide R&D in Shaanxi Province College of Plant Protection, Northwest A&F University Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2414-5784","authenticated-orcid":false,"given":"Jiwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Pharmacy Northwest A&F University Shaanxi China"},{"name":"Key Laboratory of 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