{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:05:15Z","timestamp":1790229915286,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Western flower thrips,\n                      <jats:italic>Frankliniella occidentalis<\/jats:italic>\n                      , is a major agricultural pest that is difficult to manage because of its broad host range, cryptic behavior, rapid population growth, and increasing resistance to conventional insecticides. Insect neuropeptides and their cognate G protein\u2010coupled receptors (GPCRs) have emerged as potential molecular targets for developing alternative pest management tools. In this study, CAPA (\n                      <jats:styled-content>capa<\/jats:styled-content>\n                      bility)\u00a0neuropeptide analogs were evaluated for their ability to modulate signaling through the\n                      <jats:italic>F. occidentalis<\/jats:italic>\n                      CAPA receptor (CAPA\u2010R) and to reduce thrips survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Nineteen peptides, including one native ligand, six short linear analogs, six internally cyclized analogs, and six terminally cyclized analogs, were assessed using calcium mobilization assays in Sf9 cells expressing CAPA\u2010R, dual\u2010addition assays, oral feeding bioassays, and\n                      <jats:italic>in silico<\/jats:italic>\n                      receptor\u2010ligand modeling. Most linear peptides and several internally cyclized peptides activated CAPA\u2010R, whereas terminally cyclized peptides showed limited receptor activation\n                      <jats:italic>in vitro<\/jats:italic>\n                      . Peptide feeding assays showed that nine cyclized peptides, including six internally cyclized and three terminally cyclized analogs, significantly reduced the survival of adult male thrips. No significant effects on female survival were detected. Internally cyclized peptides generally showed greater activity in feeding assays than terminally cyclized peptides. Structural modeling further suggested that cyclized peptides interact with the CAPA\u2010R ligand\u2010binding region.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      These findings indicate that cyclized CAPA peptide analogs can reduce the survival of male\n                      <jats:italic>F. occidentalis<\/jats:italic>\n                      and may provide a basis for developing peptide\u2010based control strategies. More broadly, the results support insect neuropeptide GPCRs as promising targets for next\u2010generation pest management approaches. \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.71317","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:52:29Z","timestamp":1790229149000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cyclic\n                    <scp>CAPA<\/scp>\n                    peptide analogs targeting the\n                    <scp>CAPA<\/scp>\n                    receptor induce male\u2010specific mortality in western flower thrips"],"prefix":"10.1002","author":[{"given":"Ryssa K","family":"Parks","sequence":"first","affiliation":[{"name":"USDA\u2010ARS, Horticultural Crops Disease and Pest Management Research Unit  Corvallis OR 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