{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:45:55Z","timestamp":1791773155035,"version":"4.3.4"},"reference-count":78,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Insecticide resistance management (IRM) strategies, such as rotation and mixture, rely on fitness tradeoffs and susceptible population dilution to slow resistance. While IRM is widely recommended, its robustness when a target pest's biology violates these foundational assumptions remains poorly tested. The honey bee parasite,\n                      <jats:italic>Varroa destructor,<\/jats:italic>\n                      provides a test case to evaluate these limits. For instance,\n                      <jats:italic>V. destructor's<\/jats:italic>\n                      obligate sibling mating prevents genetic dilution, resistance mutations appear to carry low fitness costs, and acaricide\u2010absorbing beeswax exerts continuous sub\u2010lethal selection even after treatment ceases. Using this system to validate IRM principles, we asked: (1) Does treatment cessation successfully restore acaricide susceptibility? and (2) Do rotation and mixture strategies effectively maintain high mite mortality when standard IRM conditions are compromised?\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      We conducted the first meta\u2010analysis of IRM outcomes in\n                      <jats:italic>V. destructor<\/jats:italic>\n                      synthesizing treatment history and efficacy data from 15 studies (nine on rotation, seven on mixtures). Modelling revealed acaricide effectiveness declined by 5.5% per year of active treatment, while sensitivity rebounded by 10.7% per year following treatment cessation. Despite this partial recovery, neither rotation nor mixture strategies were associated with improved mite mortality. Susceptibility rebounds were likely insufficient to restore the near\u2010complete kill rates rotation requires, while progressive efficacy declines undermined the baseline conditions necessary for mixtures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      Ultimately, although IRM is the standard recommendation for\n                      <jats:italic>V. destructor<\/jats:italic>\n                      , our findings demonstrate that real\u2010world implementation is unlikely to succeed without treatment\u2010history tracking and prescriptive intervention before widespread resistance is established. \u00a9 2026 The Author(s).\n                      <jats:italic>Pest Management Science<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.71341","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:41:01Z","timestamp":1791772861000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Why rotation and mixture fail: treatment history and the declining acaricide efficacy in\n                    <i>Varroa destructor<\/i>"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2573-9859","authenticated-orcid":false,"given":"Sara","family":"Bryant","sequence":"first","affiliation":[{"name":"CSIRO Black Mountain and Australian National University (ANU)  Canberra Australia"},{"name":"Australian National University (ANU)  Canberra Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4369-1019","authenticated-orcid":false,"given":"Alexander S","family":"Mikheyev","sequence":"additional","affiliation":[{"name":"Australian National University (ANU)  Canberra Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/ps.7180","article-title":"Beyond redundant kill: a fundamental explanation of how insecticide mixtures work for resistance management","volume":"79","author":"Madgwick PG","year":"2023","journal-title":"Pest Manag Sci"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1002\/ps.7939","article-title":"What is the value of rotations to insecticide resistance management?","volume":"80","author":"Madgwick PG","year":"2024","journal-title":"Pest Manag Sci"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1012944","article-title":"Simulating dynamic insecticide selection pressures for 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