{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:59:39Z","timestamp":1790747979450,"version":"4.1.0"},"reference-count":86,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016703","name":"Kansas Soybean Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016703","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Multiple herbicide resistance in Palmer amaranth (\n                      <jats:italic>Amaranthus palmeri<\/jats:italic>\n                      S. Watson) poses a serious threat to US crop production. A Palmer amaranth population (KCTR) from Kansas was found resistant to herbicides across six sites\u2010of\u2010action, including ALS\u2010, PS II\u2010, EPSPS\u2010, PPO\u2010, HPPD\u2010inhibitors and synthetic auxins. Previous physiological and metabolic studies suggested that resistance in this population is predominantly associated with enhanced herbicide metabolism, possibly mediated by cytochrome P450 (P450) and\/or glutathione S\u2010transferase (GST) enzyme activity. The aim of this study was to identify candidate genes potentially associated with multiple herbicide resistance in KCTR Palmer amaranth population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Differential gene expression analysis revealed 414, 129, 529, 152 and 688 genes differentially expressed in resistant plants as compared to susceptible, following chlorsulfuron, 2,4\u2010D, atrazine, mesotrione and lactofen treatments, respectively.\n                      <jats:italic>CYP72A219<\/jats:italic>\n                      paralogs,\n                      <jats:italic>CYP704B1\u2010like<\/jats:italic>\n                      and\n                      <jats:italic>GST\u2010ct<\/jats:italic>\n                      genes were constitutively up\u2010regulated in resistant plants as compared to susceptible. Validated by qRT\u2010PCR,\n                      <jats:italic>CYP72A219<\/jats:italic>\n                      and\n                      <jats:italic>CYP704B1\u2010like<\/jats:italic>\n                      were 3.4\u2010 to 6.6\u2010fold and 5.9\u2010 to 12.4\u2010fold up\u2010regulated in resistant plants as compared to susceptible without any treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Identifying genes associated with multiple herbicide metabolism is critical for understanding cross\u2010resistance and evaluating new herbicides for resistance risk. These candidate resistance\u2010associated genes serve as targets for functional validation studies in future to help develop molecular markers for screening broad\u2010spectrum herbicide resistance. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.71345","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:25:05Z","timestamp":1790745905000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Deciphering metabolic resistance to multiple herbicides in\n                    <scp>\n                      <i>Amaranthus palmeri via<\/i>\n                    <\/scp>\n                    transcriptome analysis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0058-5662","authenticated-orcid":false,"given":"Rishabh","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Agronomy Kansas State University  Manhattan Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaiphabi","family":"Kumam","sequence":"additional","affiliation":[{"name":"Department of Horticultural Sciences University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohit","family":"Mahey","sequence":"additional","affiliation":[{"name":"Department of Plant, Soil and Microbial Sciences Michigan State University  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7111-6287","authenticated-orcid":false,"given":"Eric","family":"Patterson","sequence":"additional","affiliation":[{"name":"Department of Plant, Soil and Microbial Sciences Michigan State University  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanzhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology Kansas State University  Manhattan Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5818-0783","authenticated-orcid":false,"given":"Sarah","family":"Lancaster","sequence":"additional","affiliation":[{"name":"Department of Agronomy Kansas State University  Manhattan Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2065-9067","authenticated-orcid":false,"given":"Mithila","family":"Jugulam","sequence":"additional","affiliation":[{"name":"Texas A&amp;M AgriLife Research and Extension Center at Beaumont  Beaumont Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1017\/S0043174500076888","article-title":"Palmer amaranth (Amaranthus palmeri) interference in soybeans (Glycine max)","volume":"42","author":"Klingaman 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