{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:02:50Z","timestamp":1790139770051,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011798","name":"Ministry of Agriculture and Rural Affairs of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011798","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Plant bacterial diseases caused by\n                      <jats:italic>Xanthomonas oryzae<\/jats:italic>\n                      pv.\n                      <jats:italic>oryzicola<\/jats:italic>\n                      (\n                      <jats:italic>Xoc<\/jats:italic>\n                      ) and\n                      <jats:italic>Xanthomonas axonopodis<\/jats:italic>\n                      pv.\n                      <jats:italic>citri<\/jats:italic>\n                      (\n                      <jats:italic>Xac<\/jats:italic>\n                      ) cause severe yield losses, and increasing resistance to existing bactericides demands novel antibacterial agents. Guided by a molecular hybridization and cationization strategy, a series of pyridine\u2010phenylamide derivatives and their cationic\n                      <jats:italic>N<\/jats:italic>\n                      \u2010alkylpyridinium analogs were designed and synthesized.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Bioassay demonstrated that cationic functionalization drastically enhanced antibacterial potency. Compound\n                      <jats:bold>B6<\/jats:bold>\n                      emerged as the most potent candidate, with median effective concentration values of 0.70\u2009\u03bcg\/mL against\n                      <jats:italic>Xoc<\/jats:italic>\n                      and 1.33\u2009\u03bcg\/mL against\n                      <jats:italic>Xac<\/jats:italic>\n                      , representing 77\u2010fold and 46.7\u2010fold improvements over bismerthiazol, respectively.\n                      <jats:italic>In vivo<\/jats:italic>\n                      trials confirmed that\n                      <jats:bold>B6<\/jats:bold>\n                      provided significant protective and curative efficacy in rice. Mechanistic studies revealed that\n                      <jats:bold>B6<\/jats:bold>\n                      not only inhibited biofilm formation and extracellular polysaccharide production but also activated rice immune responses via induction of defense enzymes (peroxidase, phenylalanine ammonia\u2010lyase, superoxide dismutase, and polyphenol oxidase) and systemic transcriptional reprogramming.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      Compound\n                      <jats:bold>B6<\/jats:bold>\n                      represents a promising dual\u2010action antibacterial lead that combines direct pathogen inhibition with host immune activation. This study validates cationic functionalization as a powerful strategy for developing next\u2010generation agrochemicals with reduced resistance risk. \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.71349","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:16:08Z","timestamp":1790136968000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel cationic pyridine\u2010phenylamide compounds: design, synthesis, and mechanism of action as antibacterial agents"],"prefix":"10.1002","author":[{"given":"Yaming","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Green Pesticides Guizhou University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Green 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