{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:44:18Z","timestamp":1791967458346,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32502551"],"award-info":[{"award-number":["32502551"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"abstract":"Abstract<\/jats:title>\n \n BACKGROUND<\/jats:title>\n Lepidopteran pests have developed severe resistance to diamide insecticides, posing a huge challenge to effective pest control, necessitating the development of novel insecticides to achieve the effective comprehensive management of pests. Forty\u2010two novel derivatives bearing substituted benzylamine moieties with chlorantraniliprole (CHL) as the lead compound were precisely design, synthesized, and evaluated for insecticidal activities against three Lepidopteran pests.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n The bioassay results showed that the LC\n 50<\/jats:sub>\n values of compounds\n A26<\/jats:bold>\n and\n A40<\/jats:bold>\n against\n Mythimna separata<\/jats:italic>\n were 0.080 and 0.163\u2009mg\u2009L\n \u22121<\/jats:sup>\n , respectively, comparable to that of CHL (LC\n 50<\/jats:sub>\n 0.124\u2009mg\u2009L\n \u22121<\/jats:sup>\n ). For\n Plutella xylostella<\/jats:italic>\n , the LC\n 50<\/jats:sub>\n values of\n A16<\/jats:bold>\n and\n A40<\/jats:bold>\n were 0.041 and 0.048\u2009mg\u2009L\n \u22121<\/jats:sup>\n , respectively, equivalent to that of CHL (LC\n 50<\/jats:sub>\n 0.049\u2009mg\u2009L\n \u22121<\/jats:sup>\n ). Additionally, compound\n A40<\/jats:bold>\n showed insecticidal activity against\n Spodoptera frugiperda<\/jats:italic>\n comparable to that of CHL (LC\n 5<\/jats:sub>\n 0.279 vs 0.174\u2009mg\u2009L\n \u22121<\/jats:sup>\n ) and exhibited significantly superior efficacy against the resistant strain (LC\n 50<\/jats:sub>\n 75.83 vs 141.75\u2009mg\u2009L\n \u22121<\/jats:sup>\n ). These results indicate that\n A40<\/jats:bold>\n exhibits excellent insecticidal efficacy against Lepidopteran pests. Calcium imaging experiments suggested that compound\n A40<\/jats:bold>\n targets the insect ryanodine receptors, which was further validated by transcriptome analysis and molecular docking assays.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n This research will provide valuable insights for the development of novel diamide insecticides containing benzylamine scaffolds. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ps.71351","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:44:56Z","timestamp":1791963896000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Discovery of diamide derivatives bearing a flexible substituted benzylamine moiety as potential ryanodine receptor activator"],"prefix":"10.1002","author":[{"given":"Fengyu","family":"Li","sequence":"first","affiliation":[{"name":"MARA Key Laboratory of Sustainable Crop Production in the Middle Reaches of the Yangtze River (Co\u2010construction by Ministry and Pro vince)\/Hubei Key Laboratory of Waterlogging Disaster and Agricultural Use of Wetland, College of Agriculture Yangtze University Jingzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Duan","sequence":"additional","affiliation":[{"name":"MARA Key Laboratory of Sustainable Crop Production in the Middle Reaches of the Yangtze River (Co\u2010construction by Ministry and Pro vince)\/Hubei Key Laboratory of Waterlogging Disaster and Agricultural Use of Wetland, College of Agriculture Yangtze University Jingzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhou","family":"Liu","sequence":"additional","affiliation":[{"name":"MARA Key Laboratory of Sustainable Crop Production in the Middle Reaches of the Yangtze River (Co\u2010construction by Ministry and Pro vince)\/Hubei Key Laboratory of Waterlogging Disaster and 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