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The World Health Organization recommends the population control of vector snails as one of the strategies to reduce the prevalence and incidence of schistosomiasis. In this study, molluscicidal and antiparasitic activities of plumbagin, a naturally sourced naphthoquinone with a range of biological effects, were evaluated against <jats:italic>B. glabrata<\/jats:italic> and cercariae of <jats:italic>S. mansoni<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>After 24\u2009h of exposure, plumbagin demonstrated molluscicidal activity at low concentrations against embryos (LC<jats:sub>50<\/jats:sub> of 0.56, 0.93, 0.68, 0.51 and 0.74\u2009\u03bcg\u2009mL<jats:sup>\u22121<\/jats:sup> for the blastula, gastrula, trochophore, veliger and hippo stage, respectively) and adult snails (LC<jats:sub>50<\/jats:sub> of 3.56\u2009\u03bcg\u2009mL<jats:sup>\u22121<\/jats:sup>). There were no changes in exposed snails\u2019 fecundity or fertility; however, plumbagin was able to increase the frequency of DNA damage and the number of hemocytes, with apoptosis and binucleation being the main hemocyte alterations. In addition, plumbagin showed death of <jats:italic>S. mansoni<\/jats:italic> cercariae in the concentration of 1.5\u00a0\u03bcg\u2009mL<jats:sup>\u22121<\/jats:sup> in 60\u2009min, while showing moderate toxicity to <jats:italic>Artemia salina<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Plumbagin proved to be a promising substance for the control of <jats:italic>B. glabrata<\/jats:italic> population, intermediate host of <jats:italic>S. mansoni<\/jats:italic>, as well as the cercariae, infective stage for humans (definitive host), while being moderately toxic to <jats:italic>A. salina, a<\/jats:italic> crustacean widely used in ecotoxicity tests. \u00a9 2022 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ps.7136","type":"journal-article","created":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T10:54:27Z","timestamp":1660992867000},"page":"5172-5183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Toxic, cytotoxic and genotoxic effect of plumbagin in the developmental stages of <i>Biomphalaria glabrata<\/i> (Say, 1818\u2010intermediate host) and cercaricidal activity against the infectious agent of schistosomiasis mansoni"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9530-8371","authenticated-orcid":false,"given":"Wilza Wanessa Melo","family":"Fran\u00e7a","sequence":"first","affiliation":[{"name":"Centro de Bioci\u00eancias, Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Morfotecnologia Universidade Federal de Pernambuco  Recife Brazil"},{"name":"Laborat\u00f3rio de Imunopatologia Keizo Asami (LIKA) Universidade Federal 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Federal de Pernambuco  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria Mendon\u00e7a Albuquerque","family":"De Melo","sequence":"additional","affiliation":[{"name":"Departamento de Biof\u00edsica e Radiobiologia Universidade Federal de Pernambuco  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana Cassandra Breitenbach Barroso","family":"Coelho","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica Universidade Federal de Pernambuco (UFPE)  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f4nica Camelo Pessoa","family":"de Azevedo Albuquerque","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunopatologia Keizo Asami (LIKA) Universidade Federal de Pernambuco  Recife Brazil"},{"name":"Departamento de Medicina Tropical, Centro de Ci\u00eancias M\u00e9dicas Universidade Federal de Pernambuco  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5150-1655","authenticated-orcid":false,"given":"Hallysson Douglas Andrade","family":"de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Departamento de Biof\u00edsica e Radiobiologia Universidade Federal de Pernambuco  Recife Brazil"},{"name":"Departamento de Bioqu\u00edmica Universidade Federal de Pernambuco (UFPE)  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"de Lima Aires","sequence":"additional","affiliation":[{"name":"Centro de Bioci\u00eancias, Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Morfotecnologia Universidade Federal de Pernambuco  Recife Brazil"},{"name":"Laborat\u00f3rio de Imunopatologia Keizo Asami (LIKA) Universidade Federal de Pernambuco  Recife Brazil"},{"name":"Departamento de Medicina Tropical, Centro de Ci\u00eancias M\u00e9dicas Universidade Federal de Pernambuco  Recife 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