{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:47:59Z","timestamp":1791967679306,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"abstract":"Abstract<\/jats:title>\n \n BACKGROUND<\/jats:title>\n \n Elevated atmospheric carbon dioxide (eCO\n 2<\/jats:sub>\n ) exacerbates feeding damage of the destructive rice pest brown planthopper (\n Nilaparvata lugens<\/jats:italic>\n ). Neuropeptide F (NPF) and short Neuropeptide F (sNPF) are core regulators of insect feeding and metabolism, yet their functions in mediating\n N. lugens<\/jats:italic>\n responses to eCO\n 2<\/jats:sub>\n remain unclear. This study aimed to elucidate the roles of\n NPF<\/jats:italic>\n and\n sNPF<\/jats:italic>\n in modulating the feeding behavior, lipid metabolism and oxidative balance of\n N. lugens<\/jats:italic>\n under eCO\n 2<\/jats:sub>\n .\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n NPF<\/jats:italic>\n \/\n sNPF<\/jats:italic>\n knockdown prolonged\n N. lugens<\/jats:italic>\n feeding duration, with more prominent effects under eCO\n 2<\/jats:sub>\n than ambient CO\n 2<\/jats:sub>\n . Silencing the two genes enriched differential expression genes in \u2018fat digestion and absorption\u2019 pathways, and it significantly elevated triglyceride and free fatty acid contents, reduced the ratio of polyunsaturated to saturated fatty acids, and triggered higher reactive oxygen species and malondialdehyde levels with weakened antioxidant capacity, ultimately increasing pest mortality. Dual gene knockdown exerted stronger impacts than single knockdown, and all phenotypic changes were amplified under eCO\n 2<\/jats:sub>\n .\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n \n NPF<\/jats:italic>\n and\n sNPF<\/jats:italic>\n coordinately regulate the feeding, lipid homeostasis and oxidative balance of\n N. lugens<\/jats:italic>\n under eCO\n 2<\/jats:sub>\n . The close correlation of their regulatory effects with lipid metabolism and oxidative stress clarifies the molecular mechanism of pest climate adaptation. This work advances climate\u2010related pest resistance research and provides promising molecular targets for brown planthopper biocontrol. \u00a9 2026 Society of Chemical Industry.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ps.71367","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:02:38Z","timestamp":1791964958000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["\n NPF<\/i>\n <\/scp>\n and\n \n sNPF<\/i>\n <\/scp>\n can regulate lipid metabolism to prevent oxidative imbalance in the brown planthopper under elevated\n \n CO\n 2<\/sub>\n <\/scp>"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5726-7545","authenticated-orcid":false,"given":"Ruichuan","family":"Duan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Agricultural and Forestry Biosecurity, Department of Entomology, College of Plant Protection Nanjing Agricultural University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinru","family":"Xiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural and Forestry Biosecurity, Department of Entomology, College of Plant Protection Nanjing Agricultural University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yewei","family":"Jia","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural and Forestry Biosecurity, Department of Entomology, College of Plant Protection Nanjing Agricultural University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqi","family":"Ren","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural and Forestry Biosecurity, Department of Entomology, College of Plant Protection Nanjing Agricultural University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2353-0218","authenticated-orcid":false,"given":"Yucheng","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute of Zoology, Chinese Academy of Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7011-1318","authenticated-orcid":false,"given":"Guijun","family":"Wan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural and Forestry Biosecurity, Department of Entomology, College of Plant Protection Nanjing Agricultural University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0770-8090","authenticated-orcid":false,"given":"Fajun","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural and Forestry Biosecurity, Department of Entomology, College of Plant Protection Nanjing Agricultural University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122720","article-title":"Comprehensive review of the basic chemical behaviours, sources, processes, and endpoints of trace element contamination in paddy soil\u2010rice systems in rice\u2010growing countries","volume":"397","author":"Ali W","year":"2020","journal-title":"J Hazard Mater"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines8040608","article-title":"Multiple genome wide association mapping models identify quantitative trait nucleotides for brown planthopper (Nilaparvata lugens) resistance in MAGIC Indica population of rice","volume":"8","author":"Satturu V","year":"2020","journal-title":"Vaccine"},{"key":"e_1_2_10_4_1","first-page":"3056","volume-title":"Impacts, Adaptation, and Vulnerability. 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