{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:51:35Z","timestamp":1791262295010,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005329","name":"Natural Science Foundation of Guizhou Province","doi-asserted-by":"publisher","award":["QKHJC\u2010MS [2026]388"],"award-info":[{"award-number":["QKHJC\u2010MS [2026]388"]}],"id":[{"id":"10.13039\/501100005329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFE0214300"],"award-info":[{"award-number":["2024YFE0214300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"abstract":"Abstract<\/jats:title>\n \n BACKGROUND<\/jats:title>\n Plant pathogenic fungi and bacteria cause substantial losses in agricultural production worldwide, and escalating resistance to conventional agrochemicals necessitates the development of novel, environmentally benign pesticides. Formononetin, a naturally occurring isoflavone, exhibits promising bioactivities, while quinazolinone and piperidine moieties serve as privileged pharmacophores in agrochemical discovery.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n A series of novel formononetin derivatives bearing piperidine\u2013quinazolinone scaffolds were designed, synthesized, and assessed for antifungal and antibacterial activities. Among them,\n T6<\/jats:bold>\n exhibited the strongest antifungal activity against\n Fusarium oxysporum<\/jats:italic>\n f. sp.\n capsicum<\/jats:italic>\n (\n Fo<\/jats:italic>\n ), with a median effective concentration (EC\n 50<\/jats:sub>\n ) of 8.2\u2009\u03bcg\/mL, which was markedly superior to that of azoxystrobin (Az, 79.7\u2009\u03bcg\/mL).\n T9<\/jats:bold>\n showed outstanding antibacterial activity against\n Xanthomonas axonopodis<\/jats:italic>\n pv.\n citri<\/jats:italic>\n (\n Xac<\/jats:italic>\n ), with an EC\n 50<\/jats:sub>\n of 1.8\u2009\u03bcg\/mL, far exceeding the activities of thiodiazole\u2010copper (TC, 79.6\u2009\u03bcg\/mL) and formononetin (FMN, 96.8\u2009\u03bcg\/mL). Notably,\n T6<\/jats:bold>\n primarily exerts an antifungal effect, whereas\n T9<\/jats:bold>\n mainly exhibits an antibacterial effect. Mechanistic studies revealed that\n T6<\/jats:bold>\n compromised plasma membrane integrity, triggered oxidative stress, and induced leakage of intracellular components in\n Fo<\/jats:italic>\n . Meanwhile,\n T9<\/jats:bold>\n suppressed\n Xac<\/jats:italic>\n growth, showed significant protective and curative activities\n in vivo<\/jats:italic>\n against\n Xac<\/jats:italic>\n , reduced swarming motility, inhibited biofilm formation, and decreased extracellular cellulase and amylase activities in a dose\u2010dependent manner. Density functional theory calculations clarified the electronic features governing the reactivity and stability of these compounds.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n These findings provide both theoretical and experimental foundations for the rational design of next\u2010generation antifungal and antibacterial agents aimed at sustainable crop protection. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ps.71376","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:05:51Z","timestamp":1791259551000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design, synthesis, and evaluation of antifungal and antibacterial activities of novel quinazolinone\u2013formononetin derivatives"],"prefix":"10.1002","author":[{"given":"Xiaoyan","family":"Pan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Green Pesticide, Center for R&D of Fine Chemicals, Guizhou University Guiyang P. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barana C.","family":"Jayawardana","sequence":"additional","affiliation":[{"name":"Department of Animal Science Faculty of Agriculture, University of Peradeniya Peradeniya Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buddhi","family":"Marambe","sequence":"additional","affiliation":[{"name":"Department of Crop Science Faculty of Agriculture, University of Peradeniya Peradeniya Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4090-8411","authenticated-orcid":false,"given":"Gefei","family":"Hao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Green Pesticide, Center for R&D of Fine Chemicals, Guizhou University Guiyang P. R. 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