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The extermination of the mosquito remains a significant issue in public health. Chemical insecticides have been used to control mosquitoes for decades. However, resistance has become a limiting factor for their control. The anthranilic diamide insecticides possess excellent insecticidal activities against Lepidoptera and its resistant strains by draining internal calcium stores on activating insect ryanodine receptors. However, the reports on the effect on mosquitoes are scarce and hence a series of novel anthranilic diamides comprising acyl thiourea substructure were synthesized and their insecticidal activities against three vector mosquito larvae namely, <jats:italic>Culex quinquefasciatus<\/jats:italic>, <jats:italic>Aedes aegypti<\/jats:italic> and <jats:italic>Anopheles stephensi<\/jats:italic> were evaluated as per WHO protocol. Also investigated the morphological observations of treated larvae.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Novel anthranilic diamides containing an acyl thiourea substructure were synthesized and structures were established by <jats:sup>1<\/jats:sup>H nuclear magnetic resonance (NMR), <jats:sup>13<\/jats:sup>C NMR, Fourier transform infrared (FTIR) and high\u2010resolution mass spectrometry (HR\u2010MS). Mosquito larvicidal activity of the title compounds <jats:bold>6\u2010a\u2013s<\/jats:bold> revealed that compound <jats:bold>6\u2010l<\/jats:bold> exhibited marked larvicidal activities against <jats:italic>C.\u00a0quinquefasciatus<\/jats:italic> and <jats:italic>A.\u00a0aegypti<\/jats:italic> 3rd instar larvae with median lethal concentrations (LC<jats:sub>50<\/jats:sub>) values of 0.0044\u2009m<jats:sc>m<\/jats:sc> and 0.0070\u2009m<jats:sc>m,<\/jats:sc> respectively, for 48\u2009hours of treatment. Compound <jats:bold>6\u2010g<\/jats:bold> exhibited larvicidal activity against <jats:italic>An.\u00a0stephensi<\/jats:italic> with LC<jats:sub>50<\/jats:sub> value of 0.0085\u2009m<jats:sc>m<\/jats:sc>. Peculiar morphological alterations in the body of the treated larvae leading to death were observed on microscopic examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Novel anthranilic diamides containing an acyl thiourea substructure were designed, synthesized and characterized. Their bioassay results demonstrated significant mosquito larvicidal activity with striking morphological alterations in the body, which should ensure forthcoming designs of highly active diamide derivatives as mosquito larvicides. \u00a9 2022 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ps.7196","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T07:04:08Z","timestamp":1663916648000},"page":"257-273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Design, synthesis, characterization and insecticidal screening of novel anthranilic diamides comprising acyl thiourea substructure"],"prefix":"10.1002","volume":"79","author":[{"given":"Dhanekula","family":"Kavyasri","sequence":"first","affiliation":[{"name":"Department of Health Research ICMR\u2010Vector Control Research Centre  Indira Nagar Puducherry 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