{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:18:40Z","timestamp":1790929120020,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T00:00:00Z","timestamp":1667001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>The use of fungicides to protect crops from diseases is an effective method, and novel environmentally friendly plant\u2010derived fungicides with enhanced performance and low toxicity are urgent requirements for sustainable agriculture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Two kinds of rosin\u2010based acylhydrazone compounds were designed and prepared. Based on the antifungal activity assessment against\n                      <jats:italic>Rhizoctonia solani<\/jats:italic>\n                      ,\n                      <jats:italic>Fusarium oxysporum<\/jats:italic>\n                      ,\n                      <jats:italic>Phytophthora capsici<\/jats:italic>\n                      ,\n                      <jats:italic>Sclerotinia sclerotiorum<\/jats:italic>\n                      , and\n                      <jats:italic>Botrytis cinerea<\/jats:italic>\n                      , acylhydrazone derivatives containing a thiophene ring were screened and showed an inhibitory effect on rice\n                      <jats:italic>R. solani<\/jats:italic>\n                      . Among them, Compound\n                      <jats:bold>4n<\/jats:bold>\n                      , with an electron\u2010withdrawing group on the benzene ring structure attached to the thiophene ring, showed optimal activity, and the EC\n                      <jats:sub>50<\/jats:sub>\n                      value was 0.981\u2009mg\u2009L\n                      <jats:sup>\u22121<\/jats:sup>\n                      , which was lower than that of carbendazim. Furthermore, it was indicated that\n                      <jats:bold>4n<\/jats:bold>\n                      could affect the mycelial morphology, cell membrane permeability and microstructure, cause the generation of reactive oxygen species in fungal cells, and damage the nucleus and mitochondrial physiological function, resulting in the cell death of\n                      <jats:italic>R. solani<\/jats:italic>\n                      . Meanwhile, Compound\n                      <jats:bold>4n<\/jats:bold>\n                      exhibited a better therapeutic effect on\n                      <jats:italic>in vivo<\/jats:italic>\n                      rice plants. However, the induction activity of\n                      <jats:bold>4n<\/jats:bold>\n                      on the defense enzyme in rice leaf sheaths showed that\n                      <jats:bold>4n<\/jats:bold>\n                      stimulates the initial resistance of rice plants by removing active oxygen, thereby protecting the cell membrane or enhancing the strength of the cell wall. Through the quantitative structure\u2013activity relationship study, the quantitative chemical and electrostatic descriptors significantly affect the binding of\n                      <jats:bold>4n<\/jats:bold>\n                      with the receptor, which improves its antifungal activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>This study provides a basis for exploiting potential rosin\u2010based fungicides in promoting sustainable crop protection. \u00a9 2022 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.7232","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T11:30:06Z","timestamp":1665574206000},"page":"655-665","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Discovery of rosin\u2010based acylhydrazone derivatives as potential antifungal agents against rice\n                    <i>Rhizoctonia solani<\/i>\n                    for sustainable crop protection"],"prefix":"10.1002","volume":"79","author":[{"given":"Renle","family":"Xu","sequence":"first","affiliation":[{"name":"Shaanxi Key Laboratory of Economic Plant Resources Development and Utilization, College of Forestry, Northwest A&amp;F University  Yangling Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihao","family":"Gu","sequence":"additional","affiliation":[{"name":"Shaanxi Key Laboratory of Economic Plant Resources Development and Utilization, College of Forestry, Northwest A&amp;F University  Yangling Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Chen","sequence":"additional","affiliation":[{"name":"Shaanxi Key Laboratory of Economic Plant Resources Development and Utilization, College of Forestry, Northwest A&amp;F University  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