{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:33:03Z","timestamp":1792204383500,"version":"4.4.0"},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFD0200504"],"award-info":[{"award-number":["2017YFD0200504"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31801739"],"award-info":[{"award-number":["31801739"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Aphids have been mainly controlled by traditional chemical insecticides, resulting in unamiable risk to the environment over the last decades. Push\u2013pull strategy is regarded as a promising eco\u2010friendly approach for aphid management through repelling aphid away and attracting their natural enemy. Methyl salicylate (MeSA), one of typical HIPVs (herbivore\u2010induced plant volatiles), can repel aphids and attract ladybugs. Our previous studies discovered a new lead compound\n                      <jats:bold>3e<\/jats:bold>\n                      , a salicylate\u2010substituted carboxyl (\n                      <jats:italic>E<\/jats:italic>\n                      )\u2010\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2010farnesene derivative that had effective aphid\u2010repellent activity. However, whether\n                      <jats:bold>3e<\/jats:bold>\n                      has attractive activity to ladybug like MeSA is unknown. Meanwhile, to discover a new derivative for both deterring aphid and recruiting ladybug is meaningful for green control of aphids.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Through the structural optimization of\n                      <jats:bold>3e<\/jats:bold>\n                      , 14 new derivatives were designed and synthesized. Among them, compounds\n                      <jats:bold>4e<\/jats:bold>\n                      and\n                      <jats:bold>4i<\/jats:bold>\n                      had good aphid (\n                      <jats:italic>Acyrthosiphon pisum<\/jats:italic>\n                      ) repellent activity, and compounds\n                      <jats:bold>3e, 4e<\/jats:bold>\n                      and\n                      <jats:bold>4i<\/jats:bold>\n                      had significant ladybug (\n                      <jats:italic>Harmonia axyridis<\/jats:italic>\n                      ) attractive activity to males. Particularly,\n                      <jats:bold>4i<\/jats:bold>\n                      exhibited manifest attractive effect on the females as well. Binding mechanism showed that\n                      <jats:bold>4i<\/jats:bold>\n                      not only bound effectively with the aphid (\n                      <jats:italic>Acyrthosiphon pisum<\/jats:italic>\n                      ) target\n                      <jats:italic>Apis<\/jats:italic>\n                      OBP9 thanks to its multiple hydrophobic interactions and hydrogen\u2010bond, but also had strong binding affinity with ladybug target\n                      <jats:italic>Haxy<\/jats:italic>\n                      OBP15 due to the suitable steric space. Additionally,\n                      <jats:bold>4i<\/jats:bold>\n                      displayed low toxicity to bee\n                      <jats:italic>Apis mellifera<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      Compound\n                      <jats:bold>3e<\/jats:bold>\n                      does exhibit attractive activity to male ladybug as MeSA. However, the new derivative\n                      <jats:bold>4i<\/jats:bold>\n                      , with both pleasant aphid\u2010repellent and ladybug\u2010attraction activities, can be considered as a novel potential push\u2013pull candidate for aphid control in sustainable agriculture. \u00a9 2022 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.7245","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T04:04:33Z","timestamp":1666152273000},"page":"760-770","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["<scp>Aphid\u2010repellent<\/scp>\n                    ,\n                    <scp>ladybug\u2010attraction<\/scp>\n                    activities, and binding mechanism of methyl salicylate derivatives containing geraniol moiety"],"prefix":"10.1002","volume":"79","author":[{"given":"Zhao\u2010Kai","family":"Yang","sequence":"first","affiliation":[{"name":"Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science China Agricultural University  Beijing P. 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