{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:04:08Z","timestamp":1788303848232,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Insect\u2010associated <jats:italic>Streptomyces<\/jats:italic> is a valuable resource for development of compounds with antibacterial potential. However, relatively little is known of the secondary metabolites produced by termite\u2010associated <jats:italic>Streptomyces.<\/jats:italic><\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Here, seven compounds including <jats:italic>o<\/jats:italic>\u2010acetaminophenol (1), phenazine\u20101,6\u2010dicarboxylic acid (2), phenylacetic acid (3), phenazinolin D (4), izumiphenazine A (5), izumiphenazine B (6) and phenazinolin E (7) were obtained from the fermentation broth of a termite\u2010associated <jats:italic>Streptomyces showdoensis<\/jats:italic> BYF17, which was isolated from the body surfaces of <jats:italic>Odontotermes formosanus<\/jats:italic>. Two additional novel derivative compounds (6a and 6b) were synthesized via acetylation and methylation, respectively. The structures of these compounds were elucidated by spectroscopic analyses. The antibacterial bioassay showed that compound 6a displayed strong inhibitory effects against <jats:italic>Pseudomonas syringae<\/jats:italic> pv<jats:italic>. actinidiae<\/jats:italic> (Psa), with a zone of inhibition (ZOI) diameter of 20.6\u2009mm, which was comparable to that of positive gentamicin sulfate with a ZOI value of 25.6\u2009mm. Furthermore, the Day 5 curative activities of both compounds 6 and 6a against kiwifruit bacterial canker were 71.5%, which was higher than those of referred oxine\u2010copper (55.0%) and ethylicin (46.8%) at a concentration of 200\u2009\u03bcg\u2009mL<jats:sup>\u22121<\/jats:sup>. In addition, the mechanism analysis based on scanning electron microscopic observation revealed that both compounds 6 and 6a destroyed the integrity of the Psa cell membrane.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The results of biological tests showed that these bioactive compounds exhibit potent antimicrobial activities, which have the potential to be developed into new antibacterial agents. \u00a9 2023 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ps.7359","type":"journal-article","created":{"date-parts":[[2023,1,14]],"date-time":"2023-01-14T05:48:39Z","timestamp":1673675319000},"page":"1800-1808","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Structural characterization, derivatization and antibacterial activity of secondary metabolites produced by termite\u2010associated <i>Streptomyces showdoensis<\/i><scp>BYF17<\/scp>"],"prefix":"10.1002","volume":"79","author":[{"given":"Zhongdi","family":"Huang","sequence":"first","affiliation":[{"name":"School of Life Sciences Anhui Agricultural University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Horticulture Anhui Agricultural University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taoshan","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Life Sciences Anhui Agricultural University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Horticulture Anhui Agricultural University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Kong","sequence":"additional","affiliation":[{"name":"School of Life Sciences Anhui 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