{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:13:46Z","timestamp":1790039626025,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Plant pathogenic fungal infections have become a severe threat to the yield and quality of agricultural products, and new green antifungal agents with high efficiency and low toxicity are needed. In this study, a series of thiasporine A derivatives containing phenylthiazole\u20101,3,4\u2010oxadiazole thione (ketone) structures were designed and synthesized, and their antifungal activities against six invasive and highly destructive phytopathogenic fungi were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The results found that all compounds showed moderate to potent antifungal activity against six phytopathogenic fungi, and most of the\n                      <jats:bold>E<\/jats:bold>\n                      series compounds showed remarkable antifungal activity against\n                      <jats:italic>Sclerotinia sclerotiorum<\/jats:italic>\n                      and\n                      <jats:italic>Colletotrichum camelliaet<\/jats:italic>\n                      . In particular, compounds\n                      <jats:bold>E1<\/jats:bold>\n                      \u2013\n                      <jats:bold>E5<\/jats:bold>\n                      ,\n                      <jats:bold>E7<\/jats:bold>\n                      ,\n                      <jats:bold>E8<\/jats:bold>\n                      ,\n                      <jats:bold>E13<\/jats:bold>\n                      ,\n                      <jats:bold>E14<\/jats:bold>\n                      ,\n                      <jats:bold>E17<\/jats:bold>\n                      , and\n                      <jats:bold>E22<\/jats:bold>\n                      showed more significant antifungal activity against\n                      <jats:italic>S. sclerotiorum<\/jats:italic>\n                      , with half\u2010maximal effective concentration (EC\n                      <jats:sub>50<\/jats:sub>\n                      ) values of 0.22, 0.48, 0.56, 0.65, 0.51, 0.39, 0.60, 0.56, 0.60, 0.63, and 0.45\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      , respectively, which were superior to that of carbendazim (0.70\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      ). Further activity studies showed that compound\n                      <jats:bold>E1<\/jats:bold>\n                      possessed superior curative activities against\n                      <jats:italic>S. sclerotiorum in vivo<\/jats:italic>\n                      and better inhibitory effects on sclerotia germination and the formation of\n                      <jats:italic>S. sclerotiorum<\/jats:italic>\n                      compared with those of carbendazim.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      This study indicates that these thiasporine A derivatives containing phenylthiazole\u20101,3,4\u2010oxadiazole thione structures might be used as antifungal agents against\n                      <jats:italic>S. sclerotiorum<\/jats:italic>\n                      . \u00a9 2023 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.7481","type":"journal-article","created":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T12:13:46Z","timestamp":1679832826000},"page":"3439-3450","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Design, synthesis and antifungal evaluation of phenylthiazole\u20101,3,4\u2010oxadiazole thione (ketone) derivatives inspired by natural thiasporine A"],"prefix":"10.1002","volume":"79","author":[{"given":"Jinchao","family":"Shi","sequence":"first","affiliation":[{"name":"Institute of Pesticides, College of Agriculture Yangtze University  Jingzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Tian","sequence":"additional","affiliation":[{"name":"Institute of Pesticides, College of Agriculture Yangtze University  Jingzhou 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