{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:27:49Z","timestamp":1791606469593,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2003,7,30]],"date-time":"2003-07-30T00:00:00Z","timestamp":1059523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fund of Scientific Research (Brussels, Belgium)"},{"name":"Mexican Government"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Methoxyfenozide (RH\u20102485) was found to be 7.5\u2010fold less toxic in terms of LD<jats:sub>50<\/jats:sub> values against last\u2010instar larvae of a greenhouse\u2010selected strain of the beet armyworm <jats:italic>Spodoptera exigua<\/jats:italic> (H\u00fcbner) that was collected in July 2001 in an experimental greenhouse for resistance at Murcia in southern Spain, in comparison with a laboratory susceptible strain. To date, the compound is the newest member of this new group of moulting hormone accelerating IGRs to reach the marketplace against Lepidoptera. To understand this different potency in the greenhouse\u2010selected <jats:italic>S exigua<\/jats:italic>, oxidative metabolism and acetylcholinesterase activities were measured in last\u2010instar larvae and adults. In addition, we determined, by the use of <jats:sup>14<\/jats:sup>C\u2010labelled methoxyfenozide, the pattern of absorption in body tissues and excretion via faeces in last\u2010instar larvae of the greenhouse\u2010selected strain and compared the results with those from the laboratory susceptible strain. It was striking that the rate of excretion was about twice as high in the greenhouse\u2010selected strain, resulting in a more rapid clearance of insecticide amounts from the insect body. Data are discussed in relation to mechanisms of lower toxicities for this new group of IGRs. Copyright \u00a9 2003 Society of Chemical Industry<\/jats:p>","DOI":"10.1002\/ps.756","type":"journal-article","created":{"date-parts":[[2003,10,28]],"date-time":"2003-10-28T03:01:26Z","timestamp":1067310086000},"page":"1203-1209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Toxicity and kinetics of methoxyfenozide in greenhouse\u2010selected <i>Spodoptera exigua<\/i> (Lepidoptera: Noctuidae)"],"prefix":"10.1002","volume":"59","author":[{"given":"Guy","family":"Smagghe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Pineda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"Carton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Del","family":"Estal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flor","family":"Budia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Vi\u00f1uela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,7,30]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"Anon Distribution map of pests No 302: Spodoptera exigua CABI Wallingford UK (1972)."},{"key":"e_1_2_6_3_2","first-page":"67","article-title":"Spodoptera exigua (Lepidoptera:Noctuidae) in siergewassen","volume":"8","author":"Van de Vrie M","year":"1977","journal-title":"Gewasbescherming"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02980868"},{"key":"e_1_2_6_5_2","unstructured":"Michigan State University(2001) available athttp:\/\/www.cips.msu.edu\/resistance\/rmdb."},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.241.4864.470"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ps.2780420204"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ento.43.1.545"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/bk-2000-0767.ch002"},{"key":"e_1_2_6_10_2","first-page":"481","volume-title":"Proc Brighton Crop Prot Conf","author":"Le DP","year":"1996"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1526-4998(200102)57:2<115::AID-PS245>3.0.CO;2-A"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9063(199809)54:1<27::AID-PS772>3.0.CO;2-N"},{"key":"e_1_2_6_13_2","volume-title":"Pesticide bioassays with arthropods","author":"Robertson JL","year":"1992"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/arch.1023"},{"key":"e_1_2_6_16_2","first-page":"475","article-title":"Insecticide resistant monitoring of tebufenozide for managing Spodoptera exigua (H\u00fcbner [1808])","volume":"26","author":"Smagghe G","year":"2000","journal-title":"Bol San Veg Plagas"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(71)90285-1"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(61)90145-9"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1006\/pest.1993.1046"},{"key":"e_1_2_6_20_2","first-page":"46","volume-title":"Proc Beltwide Cotton Conf","author":"Walton L","year":"1995"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02980973"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9063(199903)55:3<386::AID-PS922>3.0.CO;2-5"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1006\/pest.2000.2497"},{"key":"e_1_2_6_24_2","first-page":"884","volume-title":"Proc Beltwide Cotton Conf","author":"Moulton JK","year":"1999"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1603\/0022-0493-95.2.414"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ps.2780450412"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/jee\/91.6.1225"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9063(1998110)54:3<203::AID-PS809>3.0.CO;2-J"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11626-998-0093-y"}],"container-title":["Pest Management Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fps.756","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ps.756","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T10:37:02Z","timestamp":1761043022000},"score":1,"resource":{"primary":{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/10.1002\/ps.756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7,30]]},"references-count":28,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2003,11]]}},"alternative-id":["10.1002\/ps.756"],"URL":"https:\/\/doi.org\/10.1002\/ps.756","archive":["Portico"],"relation":{},"ISSN":["1526-498X","1526-4998"],"issn-type":[{"value":"1526-498X","type":"print"},{"value":"1526-4998","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,7,30]]},"assertion":[{"value":"2002-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2003-05-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2003-07-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}