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Since the banning of carbosulfan and chlorpyriphos, which were widely used against the larvae of\n                      <jats:italic>Sphodroxia maroccana<\/jats:italic>\n                      because of their harmful impact on the environment, until now there has been no pesticide against these pests. Therefore, it is particularly urgent to develop highly effective insecticidal molecules with novel scaffolds. Isoxazolines are a class of insecticides that act on \u03b3\u2010aminobutyric acid (GABA)\u2010gated chloride channel allosteric modulators. In this work, a green synthesis of novel 3,5\u2010disubstituted isoxazoline\u2010sulfonamide derivatives was achieved in water\n                      <jats:italic>via<\/jats:italic>\n                      ultrasound\u2010assisted four\u2010component reactions, and their insecticidal activities against fourth\u2010instar larvae of\n                      <jats:italic>S. maroccana<\/jats:italic>\n                      were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Most of the tested compounds showed insecticidal activity compared to fluralaner as positive control and commercially available insecticide. Especially, the isoxazoline\u2010secondary sulfonamides containing halogens (Br and Cl) on the phenyl group attached to the isoxazoline,\n                      <jats:bold>6g<\/jats:bold>\n                      (LC\n                      <jats:sub>50<\/jats:sub>\n                      \u2009=\u20090.31\u2009mg\/mL),\n                      <jats:bold>6j<\/jats:bold>\n                      (LC\n                      <jats:sub>50<\/jats:sub>\n                      \u2009=\u20090.38\u2009mg\/mL),\n                      <jats:bold>6k<\/jats:bold>\n                      (LC\n                      <jats:sub>50<\/jats:sub>\n                      \u2009=\u20090.18\u2009mg\/mL),\n                      <jats:bold>6L<\/jats:bold>\n                      (LC\n                      <jats:sub>50<\/jats:sub>\n                      \u2009=\u20090.49\u2009mg\/mL),\n                      <jats:bold>6m<\/jats:bold>\n                      (LC\n                      <jats:sub>50<\/jats:sub>\n                      \u2009=\u20090.24\u2009mg\/mL),\n                      <jats:bold>6q<\/jats:bold>\n                      (LC\n                      <jats:sub>50<\/jats:sub>\n                      \u2009=\u20090.46\u2009mg\/mL), exhibited much higher larvicidal activity than fluralaner (LC\n                      <jats:sub>50<\/jats:sub>\n                      \u2009=\u20090.99\u2009mg\/mL).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      Novel isoxazolines containing sulfonamide moieties were designed, synthesized and confirmed by two single\u2010crystal structures of\n                      <jats:bold>4e<\/jats:bold>\n                      and\n                      <jats:bold>6q<\/jats:bold>\n                      . Their bioassay results showed significant larvicidal activity with significant morphological changes\n                      <jats:italic>in vivo<\/jats:italic>\n                      . These results will lay the foundation for the further discovery and development of isoxazoline\u2010sulfonamide derivatives as novel crop protection larvicides of cork oak. \u00a9 2023 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.7686","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T22:30:47Z","timestamp":1690497047000},"page":"4847-4857","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Green synthesis, characterization, and biochemical impacts of new bioactive isoxazoline\u2010sulfonamides as potential insecticidal agents against the\n                    <i>Sphodroxia maroccana Ley<\/i>"],"prefix":"10.1002","volume":"79","author":[{"given":"Ayoub","family":"El Mahmoudi","sequence":"first","affiliation":[{"name":"Equipe de Chimie des Plantes et de Synth\u00e8se Organique et Bioorganique, URAC23, Faculty of Science, B.P. 1014, Geophysics, Natural Patrimony and Green Chemistry (GEOPAC) Research Center Mohammed V University in Rabat  Agdal Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachida","family":"Fegrouche","sequence":"additional","affiliation":[{"name":"Laboratory of Biodiversity, Ecology, and Genome (BioEcoGen), Faculty of Sciences, B.P. 1014, Biotechnologies V\u00e9g\u00e9tale et Microbienne, Biodiversit\u00e9 et Environnement (Biobio) Research Center Mohammed V University in Rabat  Agdal Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza","family":"Tachallait","sequence":"additional","affiliation":[{"name":"Chemical &amp; Biochemical Sciences Green\u2010Process Engineering (CBS) Mohammed VI Polytechnic University  Benguerir Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Pierre","family":"Lumaret","sequence":"additional","affiliation":[{"name":"Zoogeography Laboratory University Paul\u2010Val\u00e9ry Montpellier 3  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhana","family":"Arshad","sequence":"additional","affiliation":[{"name":"X\u2010ray Crystallography Unit, School of Physics Universiti Sains Malaysia  Penang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Karrouchi","sequence":"additional","affiliation":[{"name":"Laboratory of Analytical Chemistry and Bromatology, Faculty of Medicine and Pharmacy Mohammed V University in Rabat  Agdal Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9553-8310","authenticated-orcid":false,"given":"Khalid","family":"Bougrin","sequence":"additional","affiliation":[{"name":"Equipe de Chimie des Plantes et de Synth\u00e8se Organique et Bioorganique, URAC23, Faculty of Science, B.P. 1014, Geophysics, Natural Patrimony and Green Chemistry (GEOPAC) Research Center Mohammed V University in 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