{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:36:22Z","timestamp":1790422582890,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T00:00:00Z","timestamp":1692144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013091","name":"Science and Technology Major Project of Guangxi","doi-asserted-by":"publisher","award":["AA18242026"],"award-info":[{"award-number":["AA18242026"]}],"id":[{"id":"10.13039\/501100013091","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      infection seriously jeopardizes the health and safety of life of immunocompromised patients. The emergences of antifungal resistance highlight a demand to find new effective antifungal drugs.\n                      <jats:italic>Angelica sinensis<\/jats:italic>\n                      is a medicine\u2013food herb and phthalides are its characteristic components. A few of the phthalides have been reported to display satisfactory antifungal activities against plant pathogenic fungi. However, the structure\u2013activity relationships and antifungal action mechanism of phthalides remain to be further explored and elucidated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The antifungal activities of five natural phthalides and four artificial analogs were investigated, and their structure\u2013activity relationships were preliminarily elucidated in the current study. The benzene ring moiety played an essential role in their antifungal activities; the oxygen\u2010containing substituents on the benzene ring obviously impacted their activities, the free hydroxyl was favorable to the activity. Typical phthalide senkyunolide B (SENB) exhibited broad antifungal activities against human and plant pathogenic fungi, especially,\n                      <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                      . SENB affected the spore germination and hyphae growth of\n                      <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                      via down\u2010regulating phosphatidylinositol\u2010PKC\u2010calcineurin axis and the expression of\n                      <jats:italic>ENG<\/jats:italic>\n                      genes. Moreover, SENB disturbed the oxidation\u2013reduction process in\n                      <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                      to destroy the mature biofilms.\n                      <jats:italic>In vivo<\/jats:italic>\n                      experiments indicated SENB significantly prolonged survival and decreased fungal burden in mouse model of invasive pulmonary aspergillosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Phthalides could be considered as the valuable leads for the development of antifungal drug to cure plant and human disease. \u00a9 2023 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.7696","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T14:59:40Z","timestamp":1690988380000},"page":"4952-4963","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Senkyunolide B exhibits broad\u2010spectrum antifungal activity against plant and human pathogenic fungi via inhibiting spore germination and destroying the mature biofilm"],"prefix":"10.1002","volume":"79","author":[{"given":"Junfeng","family":"Tan","sequence":"first","affiliation":[{"name":"Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life and Health Sciences Northeastern University  Shenyang P. 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