{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:06:24Z","timestamp":1790906784304,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:00:00Z","timestamp":1693958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Agricultural pests have caused huge losses in agricultural production and threaten global food security. Synthetic insecticides remain the major control method. However, with the rapid development of pest resistance and the increasingly stringent regulations on pesticide usage, the development of efficient insecticides with novel structures is particularly urgent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010six novel anthranilic diamide derivatives containing the thiazole moiety were designed based on the scaffold hopping strategy. Bioassay results indicated that compound\n                      <jats:bold>6e<\/jats:bold>\n                      exhibited excellent insecticidal activity against a susceptible strain of diamondback moth (\n                      <jats:italic>Plutella xylostella<\/jats:italic>\n                      ) with a median lethal concentration (LC\n                      <jats:sub>50<\/jats:sub>\n                      ) of 0.65\u2009mg\u2009L\n                      <jats:sup>\u22121<\/jats:sup>\n                      , which was similar to chlorantraniliprole (LC\n                      <jats:sub>50<\/jats:sub>\n                      \u2009=\u20090.53\u2009mg\u2009L\n                      <jats:sup>\u22121<\/jats:sup>\n                      ). Compound\n                      <jats:bold>6e<\/jats:bold>\n                      showed marginally lower (LC\n                      <jats:sub>50<\/jats:sub>\n                      \u2009=\u200950.45\u2009mg\u2009L\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) insecticidal activity than chlorantraniliprole (LC\n                      <jats:sub>50<\/jats:sub>\n                      \u2009=\u200931.98\u2009mg\u2009L\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) on chlorantraniliprole\u2010resistant\n                      <jats:italic>P.\u2009xylostella<\/jats:italic>\n                      larvae, suggesting a cross\u2010resistance of compound\n                      <jats:bold>6e<\/jats:bold>\n                      with chlorantraniliprole (resistance ratios, 77.6\u2010fold and 60.3\u2010fold, respectively). Compound\n                      <jats:bold>6e<\/jats:bold>\n                      also showed good insecticidal activity against fall armyworm and beet armyworm with pest mortalities of 74% and 64%, respectively, at 5\u2009mg\u2009L\n                      <jats:sup>\u22121<\/jats:sup>\n                      concentration. In addition, compounds\n                      <jats:bold>6e<\/jats:bold>\n                      and\n                      <jats:bold>12a<\/jats:bold>\n                      showed delayed toxicity against red imported fire ant with mortality rates of 84% and 85% (respectively) after 5\u2009days of treatment at 1.0\u2009mg\u2009L\n                      <jats:sup>\u22121<\/jats:sup>\n                      , which were superior to that of chlorantraniliprole.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      The introduction of thiazole into anthranilic diamide scaffolds resulted in insecticidal leads\n                      <jats:bold>6e<\/jats:bold>\n                      and\n                      <jats:bold>12a<\/jats:bold>\n                      with excellent insecticidal activities and potential application in controlling red imported fire ants. The work also guides the discovery of insecticidal molecules with thiazole\u2010containing anthranilic diamide scaffold. \u00a9 2023 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.7734","type":"journal-article","created":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T22:45:08Z","timestamp":1692571508000},"page":"5260-5269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Discovery of novel thiazolyl anthranilic diamide derivatives as insecticidal candidates"],"prefix":"10.1002","volume":"79","author":[{"given":"Shuai","family":"Yang","sequence":"first","affiliation":[{"name":"National Key Laboratory of Green Pesticide, Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, College of Plant Protection South China Agricultural University  Guangzhou People's Republic of 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