{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T10:18:33Z","timestamp":1769509113244,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Chemical fungicides are the mainstay of plant disease control in agricultural production, but there are a very limited number of drugs that can effectively control plant diseases. Two series of secondary amine derivatives were synthesized using the diamine skeleton combined with saturated aromatic and aliphatic aldehydes, and their antibacterial and antifungal activities against plant pathogens were determined. In addition, the antimicrobial mechanism of the highly active compound\n                      <jats:bold>A26<\/jats:bold>\n                      was preliminarily examined against\n                      <jats:italic>Xanthomonas oryzae<\/jats:italic>\n                      (\n                      <jats:italic>Xoo<\/jats:italic>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Compound\n                      <jats:bold>A26<\/jats:bold>\n                      exhibited the highest antibacterial potency among all the target compounds, with MIC values of 3.12, 3.12 and 12.5\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      against\n                      <jats:italic>Xoo<\/jats:italic>\n                      ,\n                      <jats:italic>Xanthomonas axonopodis<\/jats:italic>\n                      pv.\n                      <jats:italic>Citri<\/jats:italic>\n                      and\n                      <jats:italic>Pseudomonas sollamacearum<\/jats:italic>\n                      , respectively. In addition, compound\n                      <jats:bold>A26<\/jats:bold>\n                      had powerful curative and protective effects against\n                      <jats:italic>Xoo<\/jats:italic>\n                      at 200\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      , and was better than the control agent Xinjunan. Preliminary mechanistic studies showed that compound\n                      <jats:bold>A26<\/jats:bold>\n                      reduced the bacterial pathogenicity by targeting cell membranes and inhibiting the secretion of extracellular polysaccharides. Meanwhile, the toxicity of compound\n                      <jats:bold>A26<\/jats:bold>\n                      to Human Embryonic Kidney 293 cells and Human Liver\u20107702 was similar to that of Xinjunan, and it had moderate toxicity according to the World Health Organization classification standard of oral exogenous toxicity, with an LD\n                      <jats:sub>50<\/jats:sub>\n                      of 245.47\u2009mg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Secondary amines have efficient and broad\u2010spectrum antibacterial activity against plant pathogenic bacteria and are expected to be a new class of candidate compounds for antibacterial drugs. \u00a9 2023 Society of Chemical Industry.<\/jats:p>\n                  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