{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:56:08Z","timestamp":1788404168759,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Wheat Fusarium crown rot (FCR) is a serious problem primarily caused by <jats:italic>Fusarium pseudograminearum<\/jats:italic>, a pathogenic agent known to produce mycotoxins, including deoxynivalenol (DON). Cyclobutrifluram, a novel succinate dehydrogenase inhibitor devised by Syngenta, has immense potential to control both nematodes and <jats:italic>Fusarium<\/jats:italic> diseases. However, its efficacy in combating <jats:italic>Fusarium<\/jats:italic> species, its ability to prevent and reverse the detrimental effects of FCR, and its impact on the production of DON by <jats:italic>F<\/jats:italic>. <jats:italic>pseudograminearum<\/jats:italic> are yet to be fully ascertained.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Cyclobutrifluram exhibited substantial inhibitory activity against <jats:italic>Fusarium<\/jats:italic> species, with half\u2010maximal effective concentration values ranging from 0.0021\u20130.0647 \u03bcg mL<jats:sup>\u22121<\/jats:sup>. It demonstrated significant inhibitory activity toward three developmental stages of <jats:italic>F<\/jats:italic>. <jats:italic>pseudograminearum<\/jats:italic>, <jats:italic>F<\/jats:italic>. <jats:italic>graminearum<\/jats:italic> and <jats:italic>F<\/jats:italic>. <jats:italic>asiaticum<\/jats:italic>. Furthermore, cyclobutrifluram showed both protective and curative activities against FCR and was rapidly absorbed by roots and transported to wheat stems and leaves. Cyclobutrifluram could also decrease DON production by <jats:italic>F<\/jats:italic>. <jats:italic>pseudograminearum<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>This investigation has revealed the potential of cyclobutrifluram as a formidable candidate fungicide, particularly in its ability to effectively combat FCR and other Fusarium\u2010related ailments. This novel compound has exceptional pathogen\u2010fighting capabilities, coupled with remarkable systemic translocation properties and a notable ability to reduce the production of DON. \u00a9 2023 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ps.7935","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T13:36:46Z","timestamp":1702561006000},"page":"2001-2010","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Inhibitory activity to <i>Fusarium<\/i> spp. and control potential for wheat Fusarium crown rot of a novel succinate dehydrogenase inhibitor cyclobutrifluram"],"prefix":"10.1002","volume":"80","author":[{"given":"Yiwen","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory for Crop Stress Resistance and High\u2010Efficiency Production, College of Plant Protection Northwest A&amp;F University  Yangling 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