{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:59:52Z","timestamp":1788965992324,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Peanut southern blight disease, caused by <jats:italic>Sclerotium rolfsii<\/jats:italic>, is a destructive soil\u2010borne fungal disease. The current control measures, which mainly employ succinate dehydrogenase inhibitors, are prone to resistance and toxicity to non\u2010target organisms. As a result, it is necessary to explore the potential of eco\u2010friendly fungicides for this disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Fourteen novel phthalide compounds incorporating amino acid moieties were designed and synthesized. The <jats:italic>in vitro<\/jats:italic> activity of analog <jats:bold>A1<\/jats:bold> [half maximal effective concentration (EC<jats:sub>50<\/jats:sub>)\u2009=\u2009332.21\u2009mg\u2009L<jats:sup>\u22121<\/jats:sup>] was slightly lower than that of polyoxin (EC<jats:sub>50<\/jats:sub>\u2009=\u2009284.32\u2009mg\u2009L<jats:sup>\u22121<\/jats:sup>). It was observed that on the seventh day, the curative activity of <jats:bold>A1<\/jats:bold> at a concentration of 600.00\u2009mg\u2009L<jats:sup>\u22121<\/jats:sup> was 57.75%, while the curative activity of polyoxin at a concentration of 300.00\u2009mg\u2009L<jats:sup>\u22121<\/jats:sup> was 42.55%. These results suggested that our compound exhibited <jats:italic>in vivo<\/jats:italic> activity. Peanut plants treated with <jats:bold>A1<\/jats:bold> showed significant agronomic improvements compared to the untreated control. Several compounds in this series exhibited superior root absorption and conduction in comparison to the endothermic fungicide thifluzamide. The growth promotion and absorption\u2010conduction experiments demonstrated the reason for the superior <jats:italic>in vivo<\/jats:italic> activity of the target compound. Cytotoxic assays have demonstrated that this series of targeted compounds exhibit low toxicity levels toward human lo2 liver cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Our results provide a new strategy for the design and synthesis of novel green compounds. Furthermore, the target compound <jats:bold>A1<\/jats:bold> can serve as a lead for further development of green fungicides. \u00a9 2024 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ps.8028","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T07:55:07Z","timestamp":1707983707000},"page":"3182-3193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Design, synthesis and bioactivity of a new class of antifungal amino acid\u2010directed phthalide compounds"],"prefix":"10.1002","volume":"80","author":[{"given":"Meizi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pesticide, College of Plant Protection Henan Agricultural University  Zhengzhou China"},{"name":"Henan Key Laboratory of Creation and Application of New Pesticide Henan Agricultural University  Zhengzhou China"},{"name":"Henan Research Center of Green Pesticide Engineering and Technology Henan Agricultural University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pesticide, College of Plant Protection Henan Agricultural University  Zhengzhou China"},{"name":"Henan Key Laboratory of Creation and Application of New Pesticide Henan Agricultural University  Zhengzhou China"},{"name":"Henan Research Center of Green Pesticide Engineering and Technology Henan Agricultural University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7374-4620","authenticated-orcid":false,"given":"Lin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pesticide, College of Plant Protection Henan Agricultural University  Zhengzhou China"},{"name":"Henan Key Laboratory of Creation and Application of New Pesticide Henan Agricultural University  Zhengzhou China"},{"name":"Henan 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Engineering and Technology Henan Agricultural University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Plant Protection and Quarantine Station of Henan Province  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pesticide, College of Plant Protection Henan Agricultural University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cropro.2007.03.010"},{"key":"e_1_2_8_3_1","first-page":"CF234\/1","volume-title":"Plant Disease Management Reports PDMR","author":"Hagan 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