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Molecules containing amides, imides, and epoxides as functional groups are prevalent in nature and find extensive application in synthesizing more intricate compounds due to their biological properties. In this context, this paper delineates the synthesis of\n N<\/jats:italic>\n \u2010phenylnorbornenesuccinimide derivatives, conducts biological assays, and carries out\n in silico<\/jats:italic>\n investigation of the protein target associated with the most potent compound in plant organisms. The phytotoxic effects of the synthesized compounds (\n 2\u201329<\/jats:bold>\n ) were evaluated on\n Allium cepa<\/jats:italic>\n ,\n Bidens pilosa<\/jats:italic>\n ,\n Cucumis sativus<\/jats:italic>\n ,\n Sorghum bicolor<\/jats:italic>\n , and\n Solanum lycopersicum<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Reaction of\n endo<\/jats:italic>\n \u2010bicyclo[2.2.1]hept\u20105\u2010ene\u20103a,7a\u2010dicarboxylic anhydride (\n 1<\/jats:bold>\n ) with aromatic amines led to the\n N<\/jats:italic>\n \u2010phenylnorbornenesuccinic acids (\n 2\u201311<\/jats:bold>\n ) with yields ranging from 75% to 90%. Cyclization of compounds (\n 2\u201311<\/jats:bold>\n ) in the presence of acetic anhydride and sodium acetate afforded\n N<\/jats:italic>\n \u2010phenylnorbornenesuccinimides (\n 12\u201320<\/jats:bold>\n ) with yields varying from 65% to 89%. Those imides were then subjected to epoxidation reaction to afford\n N<\/jats:italic>\n \u2010phenylepoxynorbornanesuccimides (\n 21\u201329<\/jats:bold>\n ) with yields from 60% to 90%. All compounds inhibited the growth of seedlings of the plants evaluated. Substance\n 23<\/jats:bold>\n was the most active against the plants tested, inhibiting 100% the growth of all species in all concentrations. Cyclophilin was found to be the enzymatic target of compound\n 23<\/jats:bold>\n .\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n \n These findings suggest that derivatives of\n N<\/jats:italic>\n \u2010phenylnorbornenesuccinimide are promising compounds in the quest for more selective and stable agrochemicals. This perspective reinforces the significance of these derivatives as potential innovative herbicides and emphasizes the importance of further exploring their biological activity on weeds. \u00a9 2024 Society of Chemical Industry.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ps.8031","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T07:18:50Z","timestamp":1708327130000},"page":"3278-3292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["\n N<\/i>\n \u2010Phenylnorbornenesuccinimide\n <\/scp>\n derivatives, agricultural defensive, and enzymatic target selection"],"prefix":"10.1002","volume":"80","author":[{"given":"Sabriny F","family":"Gomes","sequence":"first","affiliation":[{"name":"Department of Chemistry Universidade Federal de Vi\u00e7osa Vi\u00e7osa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7333-0006","authenticated-orcid":false,"given":"Elson S","family":"Alvarenga","sequence":"additional","affiliation":[{"name":"Department of Chemistry Universidade Federal de Vi\u00e7osa Vi\u00e7osa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6820-1250","authenticated-orcid":false,"given":"Vitor C","family":"Baia","sequence":"additional","affiliation":[{"name":"Department of Chemistry Universidade Federal de Vi\u00e7osa Vi\u00e7osa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denilson F","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Chemistry Universidade Federal de Lavras Lavras Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1","article-title":"United Nations Department of economic and social affairs, population division Department of Economic and Social Affairs, population division","volume":"3","author":"United Nations","year":"2022","journal-title":"World Popul Ageing"},{"key":"e_1_2_8_3_1","article-title":"Major trends in population growth around the world","volume":"3","author":"Gu D","year":"2021","journal-title":"China CDC Wkly"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2020.104669"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-409548-9.11818-4"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12355-020-00808-z"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/crso.20391"},{"key":"e_1_2_8_8_1","volume-title":"Fertilizers, Kirk\u2010Othmer Encyclopedia of Chemical Technology","author":"Taylor AW","year":"2004"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/nph.15723"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2020.104766"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2019.05.070"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.5289"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.154746"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2018.01.140"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrc.4818"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2018.03.050"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2018.04.013"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26071923"},{"key":"e_1_2_8_19_1","first-page":"1","article-title":"Study of the interference in target seed germination caused by dienamides and epoxy derivatives, in the search for new herbicides","volume":"35","author":"Ramos D","year":"2023","journal-title":"J Braz Chem Soc"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-40422005000500034"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201600092"},{"key":"e_1_2_8_22_1","volume-title":"ACD\/ChemSketch","year":"2012"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-3-33"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-011-9462-9"},{"key":"e_1_2_8_25_1","unstructured":"JamesJP Stewart MOPAC\u00ae 2016\u2014Stewart Computational Chemistry(2016)."},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.9b07839"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.5b00136"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth214"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2019.126717"},{"key":"e_1_2_8_30_1","unstructured":"RCSB Protein Data Bank. 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