{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T19:00:39Z","timestamp":1780340439100,"version":"3.54.1"},"reference-count":62,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32300447"],"award-info":[{"award-number":["32300447"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The Asian tiger mosquito, <jats:italic>Aedes albopictus<\/jats:italic>, is a competent vector for the spread of several viral arboviruses including dengue, chikungunya, and Zika. Several vital mosquito behaviors linked to survival and reproduction are primarily dependent on a sophisticated olfactory system for semiochemical perception. However, a limited number of studies has hampered our understanding of the relationship between the <jats:italic>A. albopictus<\/jats:italic> acute olfactory system and the complex chemical world.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Here, we performed a qRT\u2010PCR assay on antennae from <jats:italic>A. albopictus<\/jats:italic> of differing sex, age and physiological states, and found that <jats:italic>AalbOr10<\/jats:italic> was enriched in blood\u2010fed female mosquitoes. We then undertook single sensillum recording to de\u2010orphan AalbOr10 using a panel of physiologically and behaviorally relevant odorants in a <jats:italic>Drosophila<\/jats:italic> \u2018empty neuron\u2019 system. The results indicated that AalbOr10 was activated by seven aromatic compounds, all of which hampered egg\u2010laying in blood\u2010fed mosquitoes. Furthermore, using a post\u2010RNA interference oviposition assay, we found that reducing the transcript level of <jats:italic>AalbOr10<\/jats:italic> affected repellent activity mediated by 2\u2010ethylphenol at low concentrations (10<jats:sup>\u22124<\/jats:sup> vol\/vol). Computational modeling and molecular docking studies suggested that hydrogen bonds to Y68 and Y150 mediated the interaction of 2\u2010ethylphenol with AalbOr10.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>We reveal a potential link between aromatics\u2010induced oviposition repellency behaviors and a specific odorant receptor in <jats:italic>A. albopictus<\/jats:italic>. Our findings provide a foundation for identifying active semiochemicals for the monitoring or controlling of mosquito populations. \u00a9 2024 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ps.8064","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T18:05:44Z","timestamp":1709921144000},"page":"3603-3611","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A potential link between aromatics\u2010induced oviposition repellency behaviors and specific odorant receptor of <scp><i>Aedes albopictus<\/i><\/scp>"],"prefix":"10.1002","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0050-358X","authenticated-orcid":false,"given":"Ru","family":"Yan","sequence":"first","affiliation":[{"name":"College of Life Sciences Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peitong","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Pesticide and Environmental Toxicology Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanyi","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Pesticide and Environmental Toxicology Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Qian","sequence":"additional","affiliation":[{"name":"Institute of Pesticide and Environmental Toxicology Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guonian","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Pesticide and Environmental Toxicology Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfeng","family":"Jin","sequence":"additional","affiliation":[{"name":"College of Life Sciences Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bosheng","family":"Chen","sequence":"additional","affiliation":[{"name":"The Key Laboratory for Quality Improvement of Agricultural Products of Zhejiang Province, College of Advanced Agricultural Sciences Zhejiang A&amp;F University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8262-8827","authenticated-orcid":false,"given":"Mengli","family":"Chen","sequence":"additional","affiliation":[{"name":"The Key Laboratory for Quality Improvement of Agricultural Products of Zhejiang Province, College of Advanced Agricultural Sciences Zhejiang A&amp;F University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0269-283X.2004.00513.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3920\/9789086866267_016"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens9040266"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1405.071144"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002681"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-12-83"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.7883\/yoken.JJID.2014.576"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000706"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-12-72"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cois.2017.03.002"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2021.09.012"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.200252"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2627-5"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.07.034"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.03.002"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00039"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-016-1644-9"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036538"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0913392107"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2019.103224"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13964"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/imb.12661"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1718284115"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2013.07.008"},{"key":"e_1_2_10_26_1","first-page":"1","article-title":"A dual\u2010target molecular mechanism of pyrethrum repellency against mosquitoes","volume":"12","author":"Liu F","year":"2021","journal-title":"Nat Commun"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1417244111"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08834"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08748.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvec.12387"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fevo.2016.00024"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00094-1"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-023-01704-z"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-3-1"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21334"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv315"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2583.2005.00567.x"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2583.2006.00610.x"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1100584108"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.201665.112"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-12-82"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-749"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-2239-0"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-022-05158-1"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1302562110"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep32806"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.82922"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10886-010-9828-9"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010090"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fevo.2015.00039"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00533"},{"key":"e_1_2_10_52_1","first-page":"11","article-title":"Identification of oviposition attractants for Culex quinquefasciatus from fermented Bermuda grass infusions","volume":"8","author":"Millar JG","year":"1992","journal-title":"J Am Mosq Control Assoc"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.2987\/8756-971X(2006)21[344:VCFTSO]2.0.CO;2"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-7-315"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/ee\/8.2.206"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/ee\/10.2.186"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmedent\/36.2.158"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2915.1989.tb00241.x"},{"key":"e_1_2_10_59_1","first-page":"228","article-title":"Field and laboratory evaluations of potential oviposition attractants for Aedes albopictus (Diptera: Culicidae)","volume":"19","author":"Trexler JD","year":"2003","journal-title":"J Am Mosq Control Assoc"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2019.103213"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2023.03.005"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2022.03.006"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-020-00946-6"}],"container-title":["Pest Management Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ps.8064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:37:28Z","timestamp":1761061048000},"score":1,"resource":{"primary":{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/10.1002\/ps.8064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,22]]},"references-count":62,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/ps.8064"],"URL":"https:\/\/doi.org\/10.1002\/ps.8064","archive":["Portico"],"relation":{},"ISSN":["1526-498X","1526-4998"],"issn-type":[{"value":"1526-498X","type":"print"},{"value":"1526-4998","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,22]]},"assertion":[{"value":"2023-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}