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However, its wide application is limited owing to the low output of male mosquitoes and the risk of population replacement from the release of fertile <jats:italic>Wolbachia<\/jats:italic>\u2010infected females. This study aims to improve IIT efficiency for broader adoption.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>We assessed the impact of 10% pyriproxyfen (PPF) sticky powder exposure on <jats:italic>Wolbachia<\/jats:italic> (from <jats:italic>Culex molestus<\/jats:italic>)\u2010transinfected <jats:italic>Aedes albopictus<\/jats:italic> Guangzhou line (GUA line) (GC) mosquitoes. We found that the exposure caused chronic toxicity in adult mosquitoes without affecting the cytoplasmic incompatibility (CI)\u2010inducing capability of males. The PPF\u2010contaminated GC females exhibited significant sterilization and the ability to disseminate lethal doses of PPF to breeding sites. Subsequently, we conducted a field trial combining PPF with IIT aiming to suppress the <jats:italic>Ae.\u2009albopictus<\/jats:italic> population. This combined approach, termed boosted IIT (BIIT), showed a notable enhancement in population suppression efficiency. The improved efficacy of BIIT was attributed to the dispersion of PPF particles in the field via the released PPF\u2010contaminated male mosquitoes. During the BIIT field trial, no <jats:italic>Wolbachia w<\/jats:italic>Pip\u2010positive <jats:italic>Ae.\u2009albopictus<\/jats:italic> larvae were detected, indicating the effective elimination of the risk of <jats:italic>Wolbachia<\/jats:italic>\u2010induced population replacement. Additionally, the field trial of BIIT against <jats:italic>Ae.\u2009albopictus<\/jats:italic> resulted in the suppression of the nontarget mosquito species <jats:italic>Culex quinquefasciatus<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Our results highlight the remarkable efficiency and feasibility of combining IIT with PPF in suppressing mosquito populations, facilitating the widespread implementation of IIT\u2010based management of mosquito\u2010borne diseases. \u00a9 2024 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ps.8339","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T01:46:01Z","timestamp":1722217561000},"page":"6117-6129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Integrating pyriproxyfen into the incompatible insect technique enhances mosquito population suppression efficiency and eliminates 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