{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:34:25Z","timestamp":1792726465622,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2025,3]]},"abstract":"Abstract<\/jats:title>\n \n BACKGROUND<\/jats:title>\n \n Plant pathogenic fungi pose a severe threat to crop yield and food security. This study aims to investigate the potential antifungal activity and mechanism of action of camphor\u2010thiazole derivatives against six plant pathogenic fungi. A novel series of camphor\u2010thiazole derivatives were designed, synthesized and evaluated for their antifungal effects against\n Rhizoctonia solani<\/jats:italic>\n ,\n Fusarium graminearum<\/jats:italic>\n ,\n Valsa mali<\/jats:italic>\n ,\n Alternaria solani<\/jats:italic>\n ,\n Colletotrichum\u2009orbiculare<\/jats:italic>\n and\n Botryitis cinerea<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Most of the synthesized camphor\u2010thiazole derivatives exhibited notable antifungal activity. Amongst them, compounds\n C5<\/jats:bold>\n ,\n C10<\/jats:bold>\n and\n C17<\/jats:bold>\n showed significant activity against\n R.\u2009solani<\/jats:italic>\n with median effective concentrations (EC\n 50<\/jats:sub>\n ) values in the range 3\u20134\u2009\u03bcg\u2009mL\n \u22121<\/jats:sup>\n , demonstrating superior antifungal efficacy to the control drug boscalid (EC\n 50<\/jats:sub>\n \u2009=\u20091.23\u2009\u03bcg\u2009mL\n \u22121<\/jats:sup>\n ). Structure\u2013activity relationship and density functional theory analysis emphasized the critical role of substituent selection in optimizing the biological activity of these compounds. Moreover, preliminary mechanistic studies revealed that compound\n C5<\/jats:bold>\n induced abnormal mycelial and cellular morphology in\n R.\u2009solani<\/jats:italic>\n as observed using scanning and transmission electron microscopy, and triggered the production and accumulation of reactive oxygen species. Additionally, the increased concentration of\n C5<\/jats:bold>\n resulted in enhanced cell membrane permeability.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n \n In this study, the designed and optimized compound\n C5<\/jats:bold>\n emerged as a promising candidate for potent antifungal agents. The results demonstrate that synthesized camphor\u2010thiazole derivatives possess potent antifungal activity and can serve as lead compounds for further optimization in antifungal agent development. \u00a9 2024 Society of Chemical Industry.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ps.8563","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T05:38:29Z","timestamp":1732599509000},"page":"1592-1602","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Design and synthesis of camphor\u2010thiazole derivatives as potent antifungal agents: structure\u2013activity relationship and preliminary mechanistic study"],"prefix":"10.1002","volume":"81","author":[{"given":"Peng","family":"Dai","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Pesticide Science, College of Sciences, Nanjing Agricultural University Nanjing 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