{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:47:46Z","timestamp":1790621266468,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>To find efficient agricultural fungicides, 29 new 4\u2010thioquinazoline\u2010containing acetohydrazide derivatives were prepared and tested for their fungicidal properties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      All of the target compounds were characterized by\n                      <jats:sup>1<\/jats:sup>\n                      H and\n                      <jats:sup>13<\/jats:sup>\n                      C nuclear magnetic resonance and high\u2010resolution mass spectrometry techniques, and the molecular structure of compound\n                      <jats:bold>A2<\/jats:bold>\n                      was verified by single\u2010crystal X\u2010ray diffraction measurement. The experimental results revealed that many compounds from this series had impressive inhibition efficacies\n                      <jats:italic>in vitro<\/jats:italic>\n                      against the tested fungi. For example, compound\n                      <jats:bold>A25<\/jats:bold>\n                      was identified as the best fungicidal agent against\n                      <jats:italic>Rhizoctonia solani<\/jats:italic>\n                      with an EC\n                      <jats:sub>50<\/jats:sub>\n                      (half\u2010maximal effective concentration) value of 0.66\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      , superior to those of the commercial fungicides chlorothalonil, carbendazim and boscalid. Additionally, this compound displayed favorable protection and curative activities\n                      <jats:italic>in vivo<\/jats:italic>\n                      against rice sheath blight caused by\n                      <jats:italic>R<\/jats:italic>\n                      .\u2009\n                      <jats:italic>solani<\/jats:italic>\n                      . Antifungal mechanistic studies on compound\n                      <jats:bold>A25<\/jats:bold>\n                      indicated that this compound exerted its strong anti\n                      <jats:italic>\u2010R<\/jats:italic>\n                      .\u2009\n                      <jats:italic>solani<\/jats:italic>\n                      effects probably through an effective inhibition of fungal succinate dehydrogenase activity [half\u2010maximal inhibitory concentration (IC\n                      <jats:sub>50<\/jats:sub>\n                      )\u2009=\u20094.88\u2009\u03bc\n                      <jats:sc>m<\/jats:sc>\n                      ] and the impairment of cell membrane integrity, based on the results from enzymatic bioassays, molecular docking studies, and scanning and transmission electron microscopy observations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Acetohydrazide derivatives containing the 4\u2010thioquinazoline moiety had the potential to be employed as lead compounds for developing more efficient agricultural fungicides in the near future. \u00a9 2024 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.8566","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T05:10:09Z","timestamp":1733289009000},"page":"1624-1637","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Design, synthesis, X\u2010ray crystal structure, and antifungal evaluation of new acetohydrazide derivatives containing a 4\u2010thioquinazoline moiety"],"prefix":"10.1002","volume":"81","author":[{"given":"Guang\u2010Min","family":"Tian","sequence":"first","affiliation":[{"name":"State Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of 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