{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:54:08Z","timestamp":1789696448150,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Bacterial diseases in plants pose a serious threat to crop production, leading to substantial food loss every year. Prolonged and repeated use of a single antibacterial agent can promote resistance in pathogenic bacteria. Therefore, there is an urgent need to develop efficient antibacterial agents for the treatment of bacterial diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Sulfone derivatives containing an oxazole moiety were designed and synthesized. Subsequently, their biological activities were evaluated. The half\u2010maximal effective concentration (EC<jats:sub>50<\/jats:sub>) value of compound <jats:bold>F10<\/jats:bold> against <jats:italic>Xanthomonas oryzae<\/jats:italic> pv. <jats:italic>oryzicola<\/jats:italic> (<jats:italic>Xoc<\/jats:italic>) was 1.1\u2009mg\/L, which was higher than those of commercial antibacterial agents, thiodiazole\u2010copper (91.5\u2009mg\/L) and bismerthiazol (76.0\u2009mg\/L). The curative and protective effects of compound <jats:bold>F10<\/jats:bold> against bacterial leaf streak in rice were 43.8% and 48.4%, respectively, at 200\u2009mg\/L, which were significantly superior to those of thiodiazole\u2010copper (25.0% and 25.8%, respectively) and bismerthiazol (31.3% and 38.7%, respectively). Compound <jats:bold>F10<\/jats:bold> inhibits <jats:italic>Xoc<\/jats:italic> by increasing the permeability of the cell membrane, inhibiting the production of extracellular polysaccharides, and affecting flagellar movement on the cell membrane. In addition, <jats:bold>F10<\/jats:bold> reduces the pathogenicity of pathogenic bacteria, induces the accumulation of reactive oxygen species (ROS) in pathogenic bacteria, and produces adverse reactions. Compound <jats:bold>F10<\/jats:bold> weakens bacterial pathogenicity by affecting the signal transduction of plant hormones, programmed cell death, and enhancing the ability to resist infection through the autoimmune response of rice.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Therefore, compound <jats:bold>F10<\/jats:bold> can be used as a potential antibacterial agent in future applications. \u00a9 2024 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ps.8573","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T02:24:21Z","timestamp":1732674261000},"page":"1669-1682","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Sulfone derivatives containing an oxazole moiety as potential antibacterial agents: design, synthesis, antibacterial activity, and 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