{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:11:08Z","timestamp":1784902268688,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p><jats:italic>Botrytis cinerea<\/jats:italic> is one of the most serious plant diseases and severely threatens agricultural production. The rapidly intensifying resistance makes most commercial chemical fungicides lose control efficacy. Developing new fungicides with novel structures and modes of action is an effective measure to solve this problem.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In this work, 29 novel sulfonamide compounds containing pinacolone scaffolds were designed and synthesized based on the active substructure splicing strategy. The biological activity assay on three kinds of <jats:italic>Botrytis cinerea<\/jats:italic> strains manifested that these compounds exhibit moderate to excellent antifungal activity. Compounds <jats:bold>3a\u20101<\/jats:bold> and <jats:bold>3a\u201011<\/jats:bold> displayed the highest <jats:italic>in vitro<\/jats:italic> antifungal activity similar to control agents carbendazim, procymidone, and boscalid. Compound <jats:bold>3c<\/jats:bold> had the lowest EC<jats:sub>50<\/jats:sub> value of 1.96\u2009\u03bcg\/mL against strain PJ\u201002 compared to boscalid (6.90\u2009\u03bcg\/mL). Bioassay results on strawberry fruits and tomato pots indicated that compounds <jats:bold>3a\u20101<\/jats:bold> and <jats:bold>3a\u201011<\/jats:bold> also possess superb <jats:italic>in vivo<\/jats:italic> antifungal activity compared to control agents. The electronic conductivity measurement results showed that compound <jats:bold>3a\u20101<\/jats:bold> can significantly increase the membrane permeability of <jats:italic>Botrytis cinerea<\/jats:italic> mycelium. Scanning electron microscopy observation revealed that compound <jats:bold>3a\u20101<\/jats:bold> could cause the <jats:italic>Botrytis cinerea<\/jats:italic> mycelium to twist and break, and inhibit mycelium branching. Density functional theory calculation and molecular electrostatic potential distribution were also used to analyze the activity mechanism of target compounds.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Due to their excellent antifungal activity against <jats:italic>Botrytis cinerea<\/jats:italic>, these novel sulfonamide derivatives containing pinacolone scaffolds could be considered qualified fungicide candidates. Preliminary exploration of the mechanism suggests that this kind of compound may possess a novel mode of action. \u00a9 2025 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ps.8617","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T20:59:33Z","timestamp":1735851573000},"page":"2181-2190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Discovery of novel sulfonamide derivatives containing pinacolone moieties as fungicide candidates against <i>Botrytis cinerea<\/i>"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6536-752X","authenticated-orcid":false,"given":"Wei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pesticide Science College of Plant Protection, Shenyang Agricultural University  Shenyang 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