{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:53:19Z","timestamp":1792003999879,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Increasing the diversity of lead compounds has been shown to enhance the efficacy of diamide insecticides. Fifty novel compounds were precisely designed and synthesized utilizing fragment\u2010based assembly and virtual screening coupling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The median lethal concentration (LC\n                      <jats:sub>50<\/jats:sub>\n                      ) values of compounds X\u201030 and X\u201040 against\n                      <jats:italic>Mythimna separata<\/jats:italic>\n                      were 0.09 and 0.08\u2009mg\u2009L\n                      <jats:sup>\u22121<\/jats:sup>\n                      , respectively, which are lower than that of chlorantraniliprole (CHL, 0.11\u2009mg\u2009L\n                      <jats:sup>\u22121<\/jats:sup>\n                      ). Notably, compounds X\u201010, X\u201018, X\u201025, X\u201032 and X\u201043 had corresponding LC\n                      <jats:sub>50<\/jats:sub>\n                      values of 2.0\u2009\u00d7\u200910\n                      <jats:sup>\u22124<\/jats:sup>\n                      , 5.0\u2009\u00d7\u200910\n                      <jats:sup>\u22124<\/jats:sup>\n                      , 6.0\u2009\u00d7\u200910\n                      <jats:sup>\u22124<\/jats:sup>\n                      , 9.0\u2009\u00d7\u200910\n                      <jats:sup>\u22124<\/jats:sup>\n                      and 7.0\u2009\u00d7\u200910\n                      <jats:sup>\u22124<\/jats:sup>\n                      mg\u2009L\n                      <jats:sup>\u22121<\/jats:sup>\n                      against\n                      <jats:italic>Plutella xylostella<\/jats:italic>\n                      , respectively. The best compound X\u201010 exhibited five\u2010fold greater efficacy than CHL (1.0\u2009\u00d7\u200910\n                      <jats:sup>\u22123<\/jats:sup>\n                      \u2009mg\u2009L\n                      <jats:sup>\u22121<\/jats:sup>\n                      ). The LC\n                      <jats:sub>50<\/jats:sub>\n                      values of compounds X\u201021, X\u201029, and X\u201040 against\n                      <jats:italic>Spodoptera frugiperda<\/jats:italic>\n                      were 0.27, 0.26 and 0.25\u2009mg\u2009L\n                      <jats:sup>\u22121<\/jats:sup>\n                      , respectively, which are slightly lower than that of CHL (0.33\u2009mg\u2009L\n                      <jats:sup>\u22121<\/jats:sup>\n                      ). In the case of\n                      <jats:italic>Ostrinia furnacalis<\/jats:italic>\n                      , compound X\u201043 showed good efficacy with LC\n                      <jats:sub>50<\/jats:sub>\n                      values comparable to those of CHL (1.38\n                      <jats:italic>versus<\/jats:italic>\n                      1.57\u2009mg\u2009L\n                      <jats:sup>\u22121<\/jats:sup>\n                      ). Calcium imaging experiments demonstrated that X\u201021 acted on\n                      <jats:italic>S.\u2009frugiperda<\/jats:italic>\n                      ryanodine receptors. Furthermore, this series of compounds showed safety toward nontarget mammals compared to CHL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>The introduction of fluorinated alkoxy groups at the 3\u2010position of the pyrazole ring leads to good insecticidal activity and improved insect selectivity. \u00a9 2025 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.8678","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T06:16:04Z","timestamp":1738131364000},"page":"3074-3087","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Computer\u2010aided design of novel anthranilic diamides containing fluorinated alkoxy groups as potential ryanodine receptor 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