{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:25:20Z","timestamp":1783949120704,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Aphids are significant agricultural pests, causing extensive crop damage and transmitting plant viruses. Conventional insecticide\u2010based pest control faces challenges such as human and environmental toxicity and resistance. As alternative solutions, pheromone\u2010based repellents have emerged as a promising approach. However, the instability of key compounds like (\n                      <jats:italic>E<\/jats:italic>\n                      )\u2010\u03b2\u2010Farnesene (EBF) has limited their effectiveness in field applications. To address these limitations, this study focuses on developing novel aphid repellent compounds based on plant volatiles and nepetalactone key fragments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In this study, a series of derivatives were designed and synthesized from the lead compound\n                      <jats:bold>(\u00b1)I<\/jats:bold>\n                      by incorporating plant volatiles, leading to the discovery of two novel compounds with new skeletons,\n                      <jats:bold>IV\u201013<\/jats:bold>\n                      and\n                      <jats:bold>IV\u20104<\/jats:bold>\n                      . Through further modifications of the ring size and the alkyl substitutions, two optimized structures, compounds\n                      <jats:bold>IV\u201030<\/jats:bold>\n                      and\n                      <jats:bold>IV\u201036<\/jats:bold>\n                      , were identified, demonstrating promising aphid repellent activities. Bioassays indicated that\n                      <jats:bold>IV\u201030<\/jats:bold>\n                      (RV\u2009=\u200985.2%) and\n                      <jats:bold>IV\u201036<\/jats:bold>\n                      (RV\u2009=\u200970.3%) exhibited significantly enhanced repellent properties compared to their precursor compounds. Molecular docking studies revealed strong binding interactions of these compounds with aphid odorant\u2010binding protein 3(OBP3), providing further evidence of their improved biological efficacy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      The introduction of novel structures such as compounds\n                      <jats:bold>IV\u201030<\/jats:bold>\n                      and\n                      <jats:bold>IV\u201036<\/jats:bold>\n                      based on nepetalactone and plant volatile fragments resulted in the discovery of novel promising para\u2010pheromones for aphid control. These compounds exhibit stable and effective repellent activities, providing a solid foundation for further development of synthetic aphid repellents in integrated pest management strategies. \u00a9 2025 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.8686","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T01:31:06Z","timestamp":1738632666000},"page":"3162-3173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Discovery of novel skeletons of aphid repellents based on the key fragment of nepetalactone and plant volatiles"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9442-1821","authenticated-orcid":false,"given":"Yiming","family":"Lu","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Chemical Biology, School of Pharmacy East China University of Science and 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