{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:24:11Z","timestamp":1789079051074,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20232BAB205058"],"award-info":[{"award-number":["20232BAB205058"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32460690"],"award-info":[{"award-number":["32460690"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Limitations in the use and availability of copper\u2010based fungicides and antibiotics has led to a scarcity of bactericidal agents. It is urgent to develop green bactericides with new modes\u2010of\u2010action and effective chemotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A bioactive substructure splicing approach was applied to optimize the structure of the natural product isoquinolin\u20103\u2010carboxylic acid (IQ3CA). The structure\u2013activity relationship analysis showed that the increase of sulfur atomic oxidation state and small groups on the sulfone will be beneficial for antibacterial activities. The difulone compound <jats:bold>SF2<\/jats:bold> showed the most potent activity against <jats:italic>Xanthomonas oryzae<\/jats:italic> pv. <jats:italic>oryzae<\/jats:italic> (<jats:italic>Xoo<\/jats:italic>), <jats:italic>Ralstonia solanacearum<\/jats:italic> (<jats:italic>Rs<\/jats:italic>) and <jats:italic>Acidovorax citrulli<\/jats:italic> (<jats:italic>Ac<\/jats:italic>), with median lethal effective concentration values of 2.52, 2.62 and 1.12\u2009\u03bcg\u2009mL<jats:sup>\u22121<\/jats:sup>, respectively, which were superior to those of IQ3CA and kasugamycin. The protective and curative effects of compound <jats:bold>SF2<\/jats:bold> against <jats:italic>Ac<\/jats:italic> were 69.31% and 55.64%, respectively, which were better than those of thiodiazole copper (58.37% and 43.08%). Furthermore, preliminary mechanistic investigations indicated that compound <jats:bold>SF2<\/jats:bold> could increase membrane permeability, reduce exopolysaccharide content, and inhibit both bacterial motility and biofilm formation.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>A series of novel isoquinoline\u20103\u2010acylhydrazone derivatives incorporating thioether\/disulfone moieties were synthesized, and bioassay results showed compound <jats:bold>SF2<\/jats:bold> demonstrated remarkable antibacterial activity by disrupting bacterial membranes. \u00a9 2025 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ps.8737","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T01:41:15Z","timestamp":1740534075000},"page":"3695-3703","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Synthesis, antibacterial evaluation and preliminary mechanism study of novel isoquinoline\u20103\u2010carboxylic acid derivatives containing an acylhydrazone disulfone moiety"],"prefix":"10.1002","volume":"81","author":[{"given":"Shuaipeng","family":"Sun","sequence":"first","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyao","family":"Fang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Environment and Plant Protection Institute, Chinese Academy of Tropical Agricultural Science  Haikou 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