{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T02:35:40Z","timestamp":1789871740407,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Plant bacterial diseases have severely affected the yield and quality of agricultural products, among which kiwifruit canker and bacterial wilt disease, caused by <jats:italic>Pseudomonas syringae<\/jats:italic> pv. <jats:italic>actinidiae<\/jats:italic> (<jats:italic>Psa<\/jats:italic>) and <jats:italic>Ralstonia solanacearum<\/jats:italic> (<jats:italic>Rs<\/jats:italic>), respectively, seriously restrict the development of the related industry. However, there are few effective green agents available to target these diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Herein, we synthesized 41 novel derivatives of the natural product tryptanthrin, among which partial compounds showed noticeable antibacterial activity against <jats:italic>Psa<\/jats:italic> and <jats:italic>Rs<\/jats:italic>. Compounds <jats:bold>T7NO\u20104<\/jats:bold> and <jats:bold>T7NH\u20102<\/jats:bold> can affect bacterial biofilm formation, change the membrane permeability, and cause bacterial necrosis. Compound <jats:bold>T7NO\u20104<\/jats:bold> exhibits effective control activity against kiwifruit canker disease, with protective and curative efficiency of 75.61% and 66.84%, respectively. Compound <jats:bold>T7NH\u20102<\/jats:bold> exhibits good protective activity against tobacco wilt disease but poor curative activity. To improve its curative activity, considering the characteristic that bacterial wilt disease is more prone to outbreak under weakly acidic soil conditions, introducing a ZIF\u20108 framework to make <jats:bold>T7NH\u20102<\/jats:bold>@ZIF\u20108 nanoparticles that exhibit pH\u2010responsive release, then making <jats:bold>T7NH\u20102<\/jats:bold>@ZIF\u20108@TA through modifying with tannic acid (TA). <jats:bold>T7NH\u20102<\/jats:bold>@ZIF\u20108@TA nanoparticles exhibit superior efficacy against tobacco wilt disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>This study demonstrates that 7\u2010piperazine tryptanthrin derivatives exhibit good inhibitory activity against <jats:italic>Psa<\/jats:italic> and <jats:italic>Rs<\/jats:italic> and may be promising lead agents against plant bacterial diseases, with improved biological activity through being loaded into nanocarriers. \u00a9 2025 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ps.8757","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T11:24:22Z","timestamp":1741692262000},"page":"3943-3955","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Discovering the antibacterial activity of tryptanthrin derivatives for controlling kiwifruit canker and tobacco wilt disease"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8315-0092","authenticated-orcid":false,"given":"Mei","family":"Zhu","sequence":"first","affiliation":[{"name":"Center for Research and Development of Fine Chemicals Guizhou University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawang","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Karst Science Guizhou Normal University  Guiyang 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