{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:49:47Z","timestamp":1790200187543,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T00:00:00Z","timestamp":1742601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The emergence and increasing intensification of insect pest resistance greatly shortens the service life of commercial insecticides. Hence, the continuous development of novel insecticides is extremely necessary. Discovering new insecticide molecules based on natural products with insecticidal activity has been a popular technique and has made outstanding contributions in this field.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A series of betulin\u2010cinnamic acid\u2010related hybrid compounds was prepared by molecular hybridization through the bridge of acyloxy groups and their chemical structures were unambiguously confirmed. Against <jats:italic>A. pisum<\/jats:italic>, compounds <jats:bold>2e<\/jats:bold>, <jats:bold>3a\u20103e<\/jats:bold>, <jats:bold>3g<\/jats:bold>, <jats:bold>3i<\/jats:bold>, <jats:bold>3j<\/jats:bold>, and <jats:bold>3m<\/jats:bold> showed complete antifeedant activity at 2\u2009mg\/mL; compound <jats:bold>5b<\/jats:bold> exhibited 2.7 times the aphicidal activity of the precursor betulin. Against <jats:italic>P. xylostella<\/jats:italic>, compound <jats:bold>2l<\/jats:bold> displayed 3.9 times the insecticidal activity of betulin. Meanwhile, some interesting structure\u2013activity relationships were obtained. Furthermore, compound <jats:bold>2l<\/jats:bold> could destroy the ultrastructure of midgut cells and significantly inhibit the activity of \u03b1\u2010amylase in <jats:italic>P. xylostella<\/jats:italic> larvae. Molecular docking indicated that the lupane skeleton and <jats:italic>p<\/jats:italic>\u2010nitrocinnamoyloxy groups played a key role in the binding of compound <jats:bold>2l<\/jats:bold> to \u03b1\u2010amylase.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Compounds <jats:bold>5b<\/jats:bold> and <jats:bold>2l<\/jats:bold> could be further optimized structurally as the secondary lead compounds for the discovery of novel insecticide molecules. \u00a9 2025 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ps.8785","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T11:30:45Z","timestamp":1742729445000},"page":"4243-4255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Preparation and insecticidal activities of betulin\u2010cinnamic acid\u2010related hybrid compounds and insights into the stress response of <scp><i>Plutella xylostella<\/i><\/scp> L."],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6211-9531","authenticated-orcid":false,"given":"Xiaobo","family":"Huang","sequence":"first","affiliation":[{"name":"College of Horticulture and Plant Protection Henan University of Science and Technology  Luoyang China"},{"name":"Innovation Center of Pesticide Research, Department of Applied Chemistry College of Science, China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Hao","sequence":"additional","affiliation":[{"name":"College of Plant Protection Northwest A&amp;F University  Yangling China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Shu","sequence":"additional","affiliation":[{"name":"College of Horticulture and Plant Protection Henan University of Science and Technology  Luoyang 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