{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:48:16Z","timestamp":1790038096680,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Potatoes, a major economic crop, are significantly impacted by <jats:italic>Fusarium<\/jats:italic> dry rot, a prevalent postharvest disease. In <jats:italic>Dryopteris fragrans<\/jats:italic>, the research of phloroglucinol derivatives are mainly focused on antibacterial activity, while the inhibitory effects on phytopathogenic fungi have not been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In our study, six new phloroglucinol derivatives, Ortho\u2010desaspidin AA (<jats:bold>1<\/jats:bold>), Ortho\u2010desaspidin PA (<jats:bold>2<\/jats:bold>), Ortho\u2010desaspidin BA (<jats:bold>3<\/jats:bold>), Dryaspidin B (<jats:bold>4<\/jats:bold>), Alde\u2010iso\u2010methylaspidinol B (<jats:bold>5<\/jats:bold>), and Iso\u2010methylaspidinol P (<jats:bold>6<\/jats:bold>), and nine known phloroglucinol derivatives, were isolated from <jats:italic>D. fragrans<\/jats:italic>. And Compound <jats:bold>10<\/jats:bold>, aspidinol B, showed significant inhibitory activity against <jats:italic>Fusarium oxysporum<\/jats:italic>, <jats:italic>Fusarium graminearum<\/jats:italic>, <jats:italic>Fusarium proliferatum<\/jats:italic> with EC<jats:sub>50<\/jats:sub>\u2009=\u20093.619, 6.051, and 8.221\u2009\u03bcg\/mL, respectively, outperforming the commercial fungicide hymexazol (EC<jats:sub>50<\/jats:sub>\u2009=\u200934.88, 8.21, 17.91). Aspidinol B displayed potent <jats:italic>in vivo<\/jats:italic> antifungal activity against <jats:italic>F. oxysporum<\/jats:italic>, <jats:italic>F. graminearum<\/jats:italic>, and <jats:italic>F. proliferatum<\/jats:italic> at 10\u2009\u03bcg\/mL with an inhibitory rate of 83.26, 54.15 and 79.62%, respectively. Transcriptome analysis speculates that aspidinol B, by affecting the uptake of iron ions into the bacterium, and cause heme depletion that ultimately leads to changes in oxidation\u2010related pathways.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Aspidinol B exhibits strong inhibitory effects on <jats:italic>Fusarium<\/jats:italic>, indicating its potential use in the prevention and control strategies for potato dry rot. These results indicate that aspidinol B could be a potential fungicidal lead compound against <jats:italic>Fusarium<\/jats:italic>. \u00a9 2025 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ps.8836","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T05:36:53Z","timestamp":1745386613000},"page":"4728-4741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Antifungal phloroglucinol derivatives from <scp><i>Dryopteris fragrans<\/i><\/scp> (L.) Schott"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0931-6779","authenticated-orcid":false,"given":"Dongrui","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Life Sciences Northeast Agricultural University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxuan","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Life Sciences Northeast Agricultural University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Life Sciences Northeast Agricultural University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weicong","family":"Dai","sequence":"additional","affiliation":[{"name":"College of Life Sciences Northeast Agricultural University  Harbin 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