{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:50:20Z","timestamp":1792007420306,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Natural products have been and continue to be a significant resource for developing environmentally friendly pesticides with distinctive structures and mechanisms. Lansiumamide B (LB), a cinnamamide compound extracted from <jats:italic>Clausena lansium<\/jats:italic> seeds, has served as the lead compound for the design and synthesis of a series of cinnamamide derivatives. The fungicidal activity of these derivatives has been evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The majority of the proposed compounds displayed moderate to considerable antifungal efficacy against the tested pathogenic fungi and oomycetes, with some exhibiting broad\u2010spectrum fungicidal activities. Compound <jats:bold>B<\/jats:bold><jats:sub><jats:bold>26<\/jats:bold><\/jats:sub> showed excellent activity against <jats:italic>Colletotrichum orbiculare in vitro<\/jats:italic>, with a median effective concentration (EC<jats:sub>50<\/jats:sub>) value of 0.36\u2009\u03bcg\/mL, better than positive control boscalid (0.95\u2009\u03bcg\/mL) and the lead compound LB (60.18\u2009\u03bcg\/mL). <jats:italic>In vivo<\/jats:italic>, <jats:bold>B<\/jats:bold><jats:sub><jats:bold>26<\/jats:bold><\/jats:sub> also exhibited greater fungicidal activity against <jats:italic>C. orbiculare<\/jats:italic> than boscalid and LB. Furthermore, the study found that the mycelium cell wall was damaged after treatment with compound <jats:bold>B<\/jats:bold><jats:sub><jats:bold>26<\/jats:bold><\/jats:sub> through observation of the mycelial morphology and ultrastructure of <jats:italic>C. orbiculare<\/jats:italic>. Consequently, mycelial growth was inhibited.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The results indicated that cinnamamide compounds containing a 1,2,3,4\u2010tetrahydroisoquinoline moiety represent a novel class of antifungal active scaffold, and compound <jats:bold>B<\/jats:bold><jats:sub><jats:bold>26<\/jats:bold><\/jats:sub> has the potential to be developed into a new type of fungicide. \u00a9 2025 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ps.8858","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T09:15:19Z","timestamp":1748337319000},"page":"4863-4874","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Design and synthesis of novel cinnamamide derivatives\u2010based <scp>lansiumamide B<\/scp> as potent fungicidal candidates"],"prefix":"10.1002","volume":"81","author":[{"given":"Yizhou","family":"Yang","sequence":"first","affiliation":[{"name":"College of Plant Protection Northwest A&amp;F University  Yangling China"},{"name":"Engineering and Technology Centers of Biopesticide in Shaanxi  Yangling China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianrong","family":"Tang","sequence":"additional","affiliation":[{"name":"College of Plant Protection Northwest A&amp;F University  Yangling China"},{"name":"Engineering and Technology Centers of Biopesticide in Shaanxi  Yangling China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianrun","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Plant Protection Northwest A&amp;F University  Yangling China"},{"name":"Engineering and Technology Centers of Biopesticide in Shaanxi  Yangling 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