{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:01:15Z","timestamp":1789754475360,"version":"4.0.1"},"reference-count":56,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32360687"],"award-info":[{"award-number":["32360687"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2025,9]]},"abstract":"Abstract<\/jats:title>\n \n BACKGROUND<\/jats:title>\n \n The pine wilt disease (PWD) caused by\n Bursaphelenchus xylophilus<\/jats:italic>\n is considered the \u2018cancer\u2019 of pine trees, and protecting pine forests from the destructive impact of the nematode remains a significant challenge. Chemical control is one of the most effective methods for managing plant nematodes. Developing new nematicides is an effective strategy and an urgent need for\n Bursaphelenchus xylophilus<\/jats:italic>\n management.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Amide derivatives containing 1,2,4\u2010oxadiazole were designed and synthesized through a scaffold\u2010hopping strategy. Some target compounds exhibited significant nematicidal activities. For example, compound\n F3<\/jats:bold>\n showed a half\u2010maximal lethal concentration (LC\n 50<\/jats:sub>\n ) value of 3.63\u2009mg\/L against\n Bursaphelenchus xylophilus<\/jats:italic>\n . Compound\n F3<\/jats:bold>\n not only significantly inhibited the hatching of eggs, but also reduced the feeding, reproduction, and motility of\n Bursaphelenchus xylophilus<\/jats:italic>\n . Additionally, compound\n F3<\/jats:bold>\n induced the accumulation of lipofuscin, lipids, and reactive oxygen species (ROS) in\n Bursaphelenchus xylophilus<\/jats:italic>\n , leading to harmful oxidative stress responses. Compound\n F3<\/jats:bold>\n caused severe damage to the intestinal barrier, led to the shrinkage of the nematode surface. Interestingly, compound\n F3<\/jats:bold>\n exhibited a favorable interaction pattern with succinate dehydrogenase (SDH) and was similar to the interaction pattern of fluopyram with SDH. Compound\n F3<\/jats:bold>\n may inhibit the activity of nematode SDH, leading to blockage of electron transfer in the respiratory chain, thereby resulting in nematode death.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n \n Compound\n F3<\/jats:bold>\n can serve as a potential lead compound for SDH inhibitor, with further molecular structure optimization to discover new nematicides in the future. \u00a9 2025 Society of Chemical Industry.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ps.8878","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T05:24:32Z","timestamp":1746422672000},"page":"5234-5249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Novel amide derivatives containing an 1,2,4\u2010oxadiazole moiety as potential\n SDH<\/scp>\n inhibitors: design, synthesis, and nematicidal activity"],"prefix":"10.1002","volume":"81","author":[{"given":"Mei","family":"Zhu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Green Pesticide Center for R&D of Fine Chemicals of Guizhou University Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Du","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Green Pesticide Center for R&D of Fine Chemicals of Guizhou University Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Green Pesticide Center for R&D of Fine Chemicals of Guizhou University Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlei","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Green Pesticide Center for R&D of Fine Chemicals of Guizhou University Guiyang 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