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This underscores the need for developing bactericide alternatives with novel modes\u2010of\u2010action.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Herein, we devised a series of novel 2,5\u2010dihydro\u20103\n H<\/jats:italic>\n \u2010[1,2,4]triazino[5,6\u2010\n b<\/jats:italic>\n ]indole derivatives decorating with the disulfide moiety (\n W<\/jats:bold>\n \n 1<\/jats:bold>\n <\/jats:sub>\n \u2013W<\/jats:bold>\n \n 36<\/jats:bold>\n <\/jats:sub>\n ). Bioassay results indicated their antibacterial activity against three pathogenic bacteria [\n Xoo<\/jats:italic>\n (\n Xanthomonas oryzae<\/jats:italic>\n pv.\n oryzae<\/jats:italic>\n ),\n Xac<\/jats:italic>\n (\n Xanthomonas axonopodis<\/jats:italic>\n pv.\n citri<\/jats:italic>\n ) and\n Psa<\/jats:italic>\n (\n Pseudomonas syringae<\/jats:italic>\n pv.\n actinidiae<\/jats:italic>\n )]. Compound\n W<\/jats:bold>\n \n 1<\/jats:bold>\n <\/jats:sub>\n demonstrated eminent anti\u2010\n Xoo<\/jats:italic>\n activity\n in vitro<\/jats:italic>\n , with a median effecgtive concentration (EC\n 50<\/jats:sub>\n ) value of 0.77\u2009\u03bcg\u2009mL\n \u22121<\/jats:sup>\n , which was considerably higher than that of the reference agent thiodiazole copper (TC, EC\n 50<\/jats:sub>\n \u2009=\u2009104\u2009\u03bcg\u2009mL\n \u22121<\/jats:sup>\n ). At 200\u2009\u03bcg\u2009mL\n \u22121<\/jats:sup>\n , compound\n W<\/jats:bold>\n \n 1<\/jats:bold>\n <\/jats:sub>\n demonstrated better\n in vivo<\/jats:italic>\n control efficiency (46.09% curative activity; 51.26% protective activity) toward rice bacterial blight diseases, with a >20% increase in activity relative to that of the control TC. Mechanistic studies revealed that compound\n W<\/jats:bold>\n \n 1<\/jats:bold>\n <\/jats:sub>\n enabled the suppression of the activities of oxidoreductases including superoxide dismutase and catalase, disrupted the redox balance, and ultimately induced bacterial cell apoptosis.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n Overall, these new molecules were characterized by high antibacterial ability, reactive oxygen species targeting performance, and low toxicity. They demonstrated unprecedented potential for controlling bacterial infection. \u00a9 2025 Society of Chemical Industry.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ps.8895","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:06:15Z","timestamp":1747191975000},"page":"5413-5427","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Novel 2,5\u2010dihydro\u2010\n \n 3\n H<\/i>\n <\/scp>\n \u2010[1,2,4]triazino[5,6\u2010\n b<\/i>\n ]indole derivatives decorated with disulfide moiety are effective for treating bacterial infections by inducing reactive oxygen species"],"prefix":"10.1002","volume":"81","author":[{"given":"Guo\u2010Qing","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University Guiyang 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